The speaker reflects on things they would do differently if they restarted school, highlighting the importance of taking effective notes. They mention Obsidian University - a resource created by them and John Maverick - that teaches students how to improve their note taking, personal knowledge management, and study techniques. The course aims to help students achieve good grades in less time, enjoy college life, and build a note-taking system that fosters continuous learning. By mastering effective note taking, students can focus on enjoying learning and creating lasting memories in college.