3min snip

The Proof with Simon Hill cover image

Assessing your risk of cardiovascular disease (Lipid Series - Part 2) | Dr Thomas Dayspring

The Proof with Simon Hill

NOTE

Composition and Size Impact on Lipid Molecules in LDL Particles

The composition of LDL particles typically consists of 80% cholesterol and 20% triglycerides. However, variations in triglyceride levels can lead to a decrease in cholesterol molecules within the LDL particle and vice versa. The diameter of the particle greatly affects its volume, with even a slight size difference resulting in significant changes in the number of cholesterol molecules the particle can carry. For example, a normal-sized LDL particle with 80% cholesterol would have around 2,100 cholesterol molecules, while a similar particle with 50% triglycerides would have only 1,800 cholesterol molecules. Additionally, a smaller LDL particle with the normal composition can carry fewer cholesterol molecules, about 1,500, due to its reduced size.

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