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Ketamine: Benefits and Risks for Depression, PTSD & Neuroplasticity
Huberman Lab
Ketamine's Impact on Fighting Depression Revealed in Preclinical Model
Lack of sleep, anticipation of a positive future, and ability to imagine the future are key features of major depressive episodes. A preclinical model of learned helplessness revealed that animals injected with low dosages of ketamine, a dissociative anesthetic and NMDA receptor blocker, were able to swim for a longer period of time. This was surprising to researchers, as ketamine's properties as a blocker contradicted the observed effect in the animals.
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