Evolving Protocols in Sepsis Management

The approach to sepsis management has undergone significant evolution, transitioning from a comprehensive six-hour bundle introduced in 2004 to a more streamlined one-hour bundle by 2018. Core components have remained consistent, including obtaining blood cultures, administering antibiotics, providing fluids at a rate of 30 CCs per kg, and using pressors for persistent shock, alongside regular lactate monitoring. Over time, the recommendations have adapted, reflecting ongoing advancements in treatment strategies, including the historical context of activated protein C, steroids, and early goal-directed therapy.

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