PPAR receptors are critical for regulating metabolism and blood sugar levels, with their function diminishing as people age. There are three main types of PPARs: alpha, delta, and gamma, each playing a distinct role in metabolic health. Pio-glitizone (Actose) primarily targets PPAR gamma, while Fatty15 aims to engage all three PPAR types, favoring alpha and delta activity. This unique combination may offer superior benefits for blood sugar control and longevity compared to traditional diabetes medications like metformin, which may reduce mitochondrial ATP production. Fatty15 not only enhances mitochondrial efficiency but is also suggested to improve mitochondrial health, potentially encouraging the growth of new mitochondria, known as mitochondrial biogenesis. This interaction positions Fatty15 as a promising alternative for those seeking to optimize their metabolic health and energy production.
In this episode of The Human Upgrade, Dave Asprey is joined by Dr. Stephanie Venn-Watson, a veterinary epidemiologist and co-founder of Seraphina Therapeutics, to explore the groundbreaking discovery of C15, also known as Pentadecanoic acid. This episode uncovers how Dr. Venn-Watson's work with aging dolphins in the U.S. Navy led to the surprising revelation that C15 is an essential fatty acid, marking the first discovery of its kind in nearly a century. Through extensive research, C15 has shown powerful benefits for longevity, reducing inflammation, and promoting cellular health, which can help prevent chronic conditions like metabolic syndrome and heart disease.
Dr. Venn-Watson explains the science behind C15, its natural sources—such as grass-fed dairy and certain types of fish—and why it’s often missing from modern low-fat diets. She also dives into the clinical studies that reveal how C15 can stabilize cell membranes, reduce oxidative stress, and improve metabolic function. The episode emphasizes the importance of this ‘new’ fat for anyone seeking to optimize their health, whether through diet or supplementation.
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Timestamps and Highlights:
- 00:00:01 — Introduction by Dave Asprey
- 00:01:02 — Dr. Stephanie Venn-Watson’s Introduction
- 00:03:15 — The Discovery of C15
- 00:05:56 — C15 in Fish and Dairy
- 00:08:03 — C15’s Role in Longevity and Cellular Health
- 00:12:35 — Clinical Studies and Health Benefits
- 00:20:12 — C15 and Vegan Diets
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