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**Inflammation as potential cause of depression **
Increasing core body temperature through heat exposure, such as in a sauna, activates heat shock proteins that drive cellular changes and gene expression. Saunas mimic the benefits of low-intensity aerobic exercise, increasing heart rate and stroke volume, which contribute to longevity; regular sauna use has been linked to living seven years longer. The discomfort experienced in heat exposure leads to the release of dynorphins, which enhances the sensitivity of the endorphin system, ultimately improving the release of feel-good chemicals. Furthermore, a potential link between inflammation and depression is highlighted, suggesting that certain individuals with depression may have elevated markers of inflammation in their bodies, indicating that managing inflammation could be a key factor in addressing some cases of depression.