Assess Risks to Protect Health

A comprehensive analysis from 1946 to 2022 categorizes 15 pharmaceutical agents into low and high-risk groups based on their hepatotoxicity incidents. Low-risk medications, such as Loxapine, Talaparadone, Arepiprazole, Ciprazadone, and Lorazadone, report fewer than 10 cases of liver toxicity, while high-risk drugs like chlorpromazine, clozapine, and olanzapine show over 50 cases, some resulting in liver failure. While some newer drugs exhibit lower hepatotoxicity levels, their safety profiles are still under review due to limited time on the market, emphasizing the need for ongoing assessment of drug safety.