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Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas cover image

291 | Venki Ramakrishnan on the Biology of Death and Aging

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

NOTE

Innovative Approaches to Combat Aging

The aging process is multifaceted and complex, requiring comprehensive approaches that target various elements contributing to aging. One promising area of research focuses on senescent cells, which can be identified and eliminated using specific biomarkers. Targeting senescent cells in aging models, like mice, has shown improved aging symptoms. Another approach involves reprogramming cells to revert them towards a stem cell-like state, activating rejuvenation in different tissues and countering aging. Although this method has demonstrated effectiveness in recent studies, it poses significant challenges, including the increased risk of cancer and the need for a holistic strategy, as different organs age at varying rates. Addressing these intricacies offers a pathway to innovative solutions for combating aging.

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