Assess Before Expensive Decisions

Only 37% of patients were on a methotrexate dose above 15 mg per week before initiating biologic therapies, highlighting a trend of starting costly treatments without reaching the therapeutic dose of methotrexate first. The recommended therapeutic range for methotrexate lies between 15 and 25 mg per week. The administration typically begins with doses between 10 to 20 mg, often starting at 12.5 mg per week, and may require adjustment after four to five weeks to achieve sustained therapeutic effects. Limited benefits have been observed for doses exceeding 25 mg per week.