The neuroendocrine system undergoes activation during puberty in both women and men, leading to significant body and brain remodeling. In women, this system is reactivated during pregnancy, inducing brain changes to prepare for motherhood. After menopause, the neuroendocrine system is shut down as there is no longer a need for childbirth preparation. This shutdown results in a new remodeling phase with symptoms like neurological issues experienced by over 80% of women during menopause.

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