The embryo's neural plate folds into a tube by day 21, with the first closure being critical at the cordal end. Insufficient folic acid can lead to spina bifida due to improper DNA replication. Anencephaly can occur at the top end if tube closure is incomplete, crucial for forming brain vesicles. Environmental factors like high maternal temperature can impact tube closure, potentially leading to anencephaly.

Get the Snipd
podcast app

Unlock the knowledge in podcasts with the podcast player of the future.
App store bannerPlay store banner

AI-powered
podcast player

Listen to all your favourite podcasts with AI-powered features

Discover
highlights

Listen to the best highlights from the podcasts you love and dive into the full episode

Save any
moment

Hear something you like? Tap your headphones to save it with AI-generated key takeaways

Share
& Export

Send highlights to Twitter, WhatsApp or export them to Notion, Readwise & more

AI-powered
podcast player

Listen to all your favourite podcasts with AI-powered features

Discover
highlights

Listen to the best highlights from the podcasts you love and dive into the full episode