Understand Molecular Nuances to Decode Risks

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The distinction between the sizes of lipoprotein(a) [Lp(a)] particles and the molecular weight of apoprotein A is critical for understanding cardiovascular risk. Lp(a) contains an LDL core that can vary in size, which is often conflated with the peptide's molecular weight. Hence, the terms 'small' and 'large' can lead to confusion. Knowledge of these distinctions aids in comprehending the implications of Lp(a) levels in relation to health. Furthermore, polymorphism of the kringle structure in apoprotein A is recognized as a significant risk factor in elevated Lp(a) levels, suggesting that elevation may not be uniform across individuals, indicating a need for deeper understanding of individual physiological responses.

Episode #320. Are you part of the 20% of people with this dangerous gene? There’s a cheap, simple test you can do just once in your life to find out. Join me as I sit down with renowned lipidologist Dr Thomas Dayspring to help you understand Lipoprotein(a) and the test that might change your life.

In this episode, you’ll learn what Lp(a) is and how it can affect your cardiovascular disease risk through two key pathways. Dr Dayspring unpacks why it’s so important to test, how to ask for this test, and what to do with your results.

Specifically, we discuss:

Introduction (00:00)
Demystifying Lipoprotein(a): An Overview of its Role in Cardiovascular Health (02:54)
Genetic Inheritance Patterns and Variability of Lipoprotein(a) (10:11)
Drug Development Strategies for Reducing Lipoprotein(a) Levels (14:50)
Exploring the Functional Role and Genetic Variations of Lipoprotein(a) (20:27)
Inside the Artery Walls: Mechanisms and Structure of Lipoprotein(a) (32:34)
A Deep Dive in Production to Measurement of Lipoprotein(a) (42:32)
Identifying High-Risk Indicators for Lipoprotein(a) (58:54)
Statins and Elevated Lipoprotein(a): Understanding the Relationship (01:11:42)
Exploring PCSK9 Inhibitors in Lipoprotein(a) Management (01:20:30)
Emerging Treatments and Future Therapies for Lowering Lipoprotein(a) (01:31:22)
Exploring Lifestyle Considerations and Alternative Therapies (01:34:42)
Oxidized Phospholipids and Their Role in Cardiovascular Health (01:43:15)
Relationship Between Oxidized Phospholipids and Lipoprotein(a) (01:52:00)
Understanding Aortic Valve Calcification and Its Link to Lipoprotein(a) (01:59:40)
Key Takeaways and Future Landscape of Lipoprotein(a) Treatments (02:06:52)
Conclusion and Final Remarks (02:13:30)

Connect with Dr Thomas Dayspring on Twitter/X. Listen to our previous lipid series and download the cheat sheet here.

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Simon Hill, MSc, BSc (Hons)

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