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The Iron Law Prohibition
People always use drugs to meet their needs and get creative when they can't find a certain method. This aligns with the iron law prohibition that happens when authorities crack down on readily supplied drugs, leading to the rise of harder-to-detect alternatives like fentanyl. Once a new presence enters the drug market, it's hard to put it back in the bottle as people will try to add to it or cut it to achieve the ideal high.