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LEVELS – A Whole New Level cover image

#224 - How the keto diet may ease depression in bipolar disorder and other mental health conditions | Iain Campbell, Bret Scher & Dominic D’Agostino

LEVELS – A Whole New Level

NOTE

The Link Between Exercise, Lactate, and Manic Episodes in Bipolar Disorder

Exercise can improve people in depression states, but intense exercise can be a trigger for many people with bipolar disorders/nModerate intensity exercise below lactate threshold appears to be beneficial/nHigher intensity exercise can trigger manic episodes/nImporting additional fuel source like lactate into the brain can lead to heightened brain activity/nGlutamate and lactate flooding the brain after exercise may be a risk factor for manic episodes/nMetabolic overdrive, glutathosis, and hyperglycolysis post-exercise state is a significant risk for mania/nA ketogenic diet can increase glutamate metabolism in the brain/nUnique metabolic states could reveal aspects of the condition for optimizing ketogenic diet intervention

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