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Video Episode | Mr. Happy | The Next Generation - Part 2
In Search of Insight
Immune Response Fuels Growth
Mitochondrial Complex I, or NADH dehydrogenase, plays a crucial role in cellular metabolism by converting NADH back to NAD, enabling electrons to progress through the electron transport chain. However, when interferon gamma is elevated, it inhibits Complex I, leading to an accumulation of NADH. This excess NADH can redirect metabolism towards the NADP transhydrogenase pathway, resulting in increased NADPH levels. The elevated NADPH is essential for promoting hormone and cholesterol biosynthesis as well as tissue generation. This suggests that the innate immune response, particularly through cytokine elevation, significantly influences growth and tissue adaptations, highlighting its pivotal role in orchestrating responses to exercise.
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