Acute Management Strategies for Sickle Cell Crises

In cases of brisk hemolysis, characterized by rapid drops in hemoglobin, support through transfusions is essential to enhance oxygen delivery. Attention must be paid to the type and screen to identify potential new antibodies and ensure compatibility with minor red cell antigens to minimize hemolytic transfusion reactions. In severe instances, intravenous immunoglobulin (IVIG) and steroids may be administered to mitigate immune-related complications. Young patients may retain some splenic function, making them susceptible to splenic sequestration crises, which involve significant splenomegaly and a marked decrease in hemoglobin and platelets. This condition poses risks of hypovolemic shock as the spleen absorbs blood components. Recognizing splenic sequestration is crucial, given its serious implications and the need for careful management of both hemodynamics and transfusion strategies.