#533: Making Sense of Omega-3 Supplement Trials – Prof. JoAnn Manson, MD, DrPH
Sigma Nutrition Radio
Nuance Reveals Value in Null Findings
In evaluating primary outcomes of major cardiovascular events, it's crucial to recognize the significance of nuanced findings beyond an initial 8% reduction that is deemed non-significant. Secondary outcomes reveal critical insights, such as a 28% significant reduction in myocardial infarction. Subgroup analyses highlight that individuals with lower baseline fish consumption saw a 19% reduction in major cardiovascular events and a 40% reduction in heart attacks, indicating targeted benefits. Furthermore, a striking 70% reduction in heart attack risk among African American and Black participants stands out, despite not being associated with lower fish consumption. These findings emphasize the importance of examining secondary outcomes and demographic variances to draw meaningful conclusions in clinical research.
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