Balance Pleasure and Necessity

High doses of specific drugs can effectively eradicate hunger and thirst, though individual sensitivity to these medications can vary significantly. Some patients demonstrate a notable decrease in their motivation for various essential behaviors, including eating and drinking, due to the drug’s action on the hypothalamus and brainstem areas involved in appetite regulation. These substances also impact reward centers in the brain, potentially diminishing motivation for behaviors that are not necessarily undesirable. The challenge lies in the inability to selectively modify the functioning of the reward pathway, as its neurological structure is relatively straightforward.