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Healthspan, Lifespan, and the Biology of Aging

a16z Podcast

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More Coffee, More Protection

Drinking multiple cups of coffee daily is associated with protective effects against cardiovascular and all-cause mortality based on retrospective analyses conducted in large populations. The studies indicate that the more cups of coffee consumed, the more protective the effect, with higher amounts being beneficial. While some may consider five cups a day to be high, it is essential to have a sufficient number of participants to draw accurate conclusions. Additionally, the speaker highlights the enjoyment of coffee. The conversation shifts towards the topic of supplements, with the speaker mentioning the intention to try metformin and rapamycin. However, they currently focus on intermittent fasting, following a 'lazy' version by skipping dinner a couple of days a week.

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