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Episode 314 | Pain & Pleasure: Decoding the Dopamine and Chronic Pain Connection with Anna Lembke, MD

Pain Science Education

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Understanding Dopamine: Stimulants vs. Exercise

Dopamine release occurs through different mechanisms depending on the activity. Stimulants like caffeine directly release dopamine into the reward pathway, reinforcing the behavior immediately. In contrast, exercise, such as running on a treadmill, triggers a delayed dopamine release in response to perceived cellular injury, indicating a distinct biological response. This highlights the varied impacts of behaviors on neurotransmitter release and emphasizes that the timing and nature of dopamine responses are influenced by whether the activity is a direct stimulant or an exertion that challenges the body.

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