Considerations for T3 Supplementation in Cases of Downregulated D1 and D2

Patients who are insulin resistant and have low grade inflammation may not feel better even if their TSH improves with T4./nIn such cases, giving T3 might be more appropriate as it bypasses the step where T4 could be turned into reverse T3./nHowever, it may be difficult for patients to tolerate the regular version of T3 drug called cyto-mel.

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