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#485 — The New Science of Cancer

Making Sense with Sam Harris

00:00

Microenvironment Limits CAR T Success In Solid Tumors

  • CAR-T works well in hematologic malignancies but struggles in solid tumors due to the suppressive tumor microenvironment that blocks T-cell penetration.
  • Mukherjee says solid tumors' supporting stroma, vessels, and immune cells create a soil CAR-Ts can't easily infiltrate, prompting combo strategies to recondition the microenvironment.
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