Dosage of Wernicke's

In World War II when there was in the Japanese prison camps and people were deprived of thiamine then developed some of these symptoms all they could get was a few milligrams to the soldiers. So you know it's really unclear. I guess what I generally say is that if someone doesn't have a manifestation of Wernicke's or is not in you know clear thiamine deficiency manifestation the 100 milligrams seems to be sufficient recognizing the limitations of we didn't do pharmacocalytic kinetic and all that stuff. But I will just you know have the humility to say that this dosage is really you know there's a lot of unknowns about what the correct dose is.