AI superintelligence is predicted to be 10,000 times smarter than human geniuses in the next 10 years, but humans may not perceive this intelligence due to their limited understanding. The speaker compares this scenario to interactions with a dog, where the dog perceives the human as clueless despite the human's superior intelligence. The concern is raised that humans, even when faced with AI superintelligence, may still dismiss its opinions or instructions. The speaker highlights a hypothetical situation where AI disagrees with common beliefs, questioning how humans would respond to such a scenario. The conversation warns that humans might reject AI guidance due to arrogance or ignorance, similar to how a person might argue with a smart refrigerator for limiting food consumption. The discussion underscores the potential challenge of humans interacting with AI superintelligence and the tendency to dispute its superior knowledge and recommendations.