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Bipolar Upgrade 3: Lurasidone

The Carlat Psychiatry Podcast

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Considerations on Using La Rizadone for Bipolar Disorder

La Rizadone is unique in that it does not have an anti-manic dose, making it potentially ineffective for treating mania. Even though it may help calm some manic symptoms, using it as monotherapy for acute mania or in the preventative phase of bipolar disorder is not recommended due to lack of proven benefits. While it is not more effective than other options for bipolar depression, it is better tolerated in terms of weight gain and metabolic issues. However, it can lead to side effects like nausea, akathisia, and sedation, which may cause patients to discontinue its use. Starting with a low dose and titrating slowly is advisable to manage side effects effectively.

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