Navigating the Complexities of Dopamine Partial Agonists and Antipsychotics

Dopamine partial agonists may lead to the occupancy of over 80% of D2 receptors, reducing the effectiveness of dopamine antagonists. In cases where a patient on a long-acting, a bilefi, air purposol experiences breakthrough psychosis, discontinuing the partial agonist and gradually allowing it to wash out may be necessary. This process, with an average half-life of 46.5 days, might take approximately 232.5 days. Clozapine is highlighted as a gold standard treatment option due to its unique mechanisms that are not directly affected by dopamine partial agonists.