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Managing Weight Gain from Psychiatric Medications with Dr. Michael Cummings
Psychiatry & Psychotherapy Podcast
Beware the Weight Gain Cycle
Central adiposity leads to increased abdominal fat that is metabolically active and promotes inflammation, creating a self-reinforcing cycle of weight gain. Certain medications can exacerbate this issue by acting as H1 histamine antagonists, which decrease basal metabolic rate and reduce calorie burning. Additionally, these medications antagonize 5-HT2C receptors in the hypothalamus, affecting satiety and hunger cues, further contributing to weight gain.
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