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The Role of Peptides in the Body and the Importance of Microdosing
Peptides are naturally occurring signaling molecules in the body, unlike pharmaceutical drugs which often do not align with the body's intrinsic systems. The body recognizes peptides and knows how to utilize them effectively. The administration of peptides, particularly GLP1, should be approached with careful consideration of dosages; smaller, microdoses can lead to more favorable outcomes and minimize side effects compared to higher doses, which can cause adverse reactions due to excessive hormonal signal delivery. Specifically, GLP1 plays a crucial role in regulating appetite through its interaction with leptin and ghrelin, both essential for hunger signaling. In individuals with metabolic issues such as obesity and type 2 diabetes, deficiency in GLP1 is common, which disrupts leptin and ghrelin's signaling pathways. This suggests that microdosing GLP1 could help restore hormonal balance, offering potential therapeutic benefits beyond weight loss, including applications for autoimmune diseases and neuroinflammation. The prevalent practice of high-dose administration overlooks the potential of peptides when used in a more nuanced manner. Thus, there is a significant need to reevaluate and explore microdosing strategies for a broader range of health concerns.