Some individuals thrive on vegan diets due to unique metabolic flexibility and significant microbiome shifts. Long-term success on vegan diets is rare, with only a few individuals thriving beyond five years, often attributed to bio-individuality and microbiome capacity. This contrasts with observations of more individuals experiencing challenges on plant-based diets after five years unless meticulously supplementing. The emerging data supports the role of microbiome in diet outcomes, with only a very few individuals capable of long-term success on a vegan diet.

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