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The Peter Attia Drive cover image

#253 ‒ Hormone replacement therapy and the Women’s Health Initiative: re-examining the results, the link to breast cancer, and weighing the risk vs reward of HRT | JoAnn Manson, M.D.

The Peter Attia Drive

INSIGHT

Statin Use in WHI

  • At the start of the Women's Health Initiative (WHI) in the early-mid 90s, only 7% of participants used statins.
  • Statin use increased to over 25% during the trial and reached 40-50% with longer follow-up.
  • This significant rise reflects changing medical practice and increasing awareness of cardiovascular risk factors.
  • Today, ASCVD risk is managed much more aggressively with lipid-lowering therapy and blood pressure management.
  • WHI researchers published on the increasing medication use in JAMA in 2013.
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