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Mitochondria

In Our Time

Beware the Mother's Curse

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The mother's curse hypothesis illustrates an evolutionary quirk where mitochondrial DNA, inherited exclusively from mothers, can harbor harmful mutations specifically affecting males. While negative mutations detrimental to females are naturally selected against and eliminated, those that benefit females but harm males persist since they are not subjected to the same selective pressures. Consequently, male mitochondrial DNA often carries detrimental mutations, posing a significant evolutionary consequence that shapes male fitness and reproductive success.

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