Some diseases and disorders can be inherited in a recessive manner, while others are inherited dominantly. In recessive inheritance, there is a backup gene that compensates for any dysfunction caused by a mutation in one gene. However, in dominantly inherited disorders, a mutation in one gene can lead to a toxic gain of function, where the protein produced by the gene is changed in a way that is detrimental to the organism. This overrides any functionality provided by the other gene. Recessive mutations usually result in a loss of function, while dominant mutations result in a gain of function that is harmful to the organism.
In this episode, Dr Matt and Dr Mike discuss how humans realised that bacteria could fight off viruses using sequences in their DNA called, CRISPR. Today, CRISPR technology is being used to cure cancer and investigate the cause of genetic disease.
For a video of Dr Mike teaching about CRISPR, click HERE!
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