The role of estrogen in inhibiting luteinizing hormone secretion

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Estrogen inhibits luteinizing hormone secretion via the pituitary.
This is important when considering drugs used to replace or increase testosterone.
GNRH tells the pituitary to make LH and FSH, which tells the testes to make testosterone and small amounts of DHT.
Less than 1% of siphoned testosterone is used to make estrogen.
The balance of the system is important to consider.
The amount of testosterone exerting its biologic effect on the androgen receptor is a key factor.

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In this special episode of The Drive, Peter provides a comprehensive overview of the various endocrine systems: the thyroid system, the adrenal system, and the sex hormone system (for both men and women). He walks through the basic biology and the feedback cycles that regulate the production of these hormones and discusses the various options for the treatment of hormone deficiencies. In addition, Peter delves into hormone replacement therapy (HRT), providing nuanced insights into its appropriate usage and the clinical approach he adopts when working with patients.

Peter supplements these explanations with whiteboard illustrations. For a more complete understanding, we highly recommend watching these videos over just listening. The videos can be found on our YouTube channel or on the show notes page.

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