When AI and Genomics Collide
a16z Podcast
Decoding the Genotype-Phenotype Connection in CRISPR Screens
When different cells are placed in separate wells, it becomes difficult to reconcile the variations. However, pooling all the cells eliminates these issues and allows for a genome-wide CRISPR screen. This enables the measurement of genetic interventions on a large scale, providing insights into the genotype-phenotype connection. Understanding this connection is crucial for developing effective therapeutic interventions. It's a truly engineered approach to discovery, accelerating the understanding and modification of cellular phenotypes.
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