Prothrombin Complex Concentrates (PCCs) for PharmDs
Special Guest: Scott Dietrich, PharmD, BCCCP
Show Notes: https://pharmacytodose.files.wordpress.com/2019/12/pccs-for-pharmds-show-notes.pdf
Show References: https://pharmacytodose.files.wordpress.com/2019/12/pccs-for-pharmds-references.pdf
3:05 – Anticoagulation reversal pre-PCC
5:18 – Brief history of PCC
6:45 – Current role for 3-factor PCC
7:56 – When should we be using PCC?
10:00 – Role of PCC for non-reversal indications
13:20 – Weight-based v. Fixed-dose Kcentra
15:39 – Why fixed-dose Kcentra?
17:33 – When to re-dose Kcentra?
18:50 – Kcentra when INR < 2
20:20 – Guideline-recommended anticoagulation reversal
22:30 – How does Kcentra differ from FEIBA?
23:48 – FEIBA dosing strategy
24:15 – Kcentra for DOAC reversal
28:22 – FEIBA for DOAC reversal
30:02 – FEIBA v. Kcentra for DOAC reversal
30:25 – FEIBA v. KCentra for warfarin reversal
33:32 – Should we have Kcentra and FEIBA on formulary?
34:26 – Weight-based v. Fixed-dose FEIBA for DOAC reversal
35:20 – Pros/Cons of Andexxa
37:14 – PCC v. Andexxa
37:45 – Andexxa’s cost
40:10 – How would Scott reverse his AC?
43:20 – Pharmacist’s role
45:54 – PCC take home points
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