Genetic Predisposition and Fat Storage in the Body

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Genetically, individuals have differences in their predisposition to obesity and fat storage. Some people have a larger storage space in their adipose tissue, while others have less. This storage space acts as a personal fat threshold - if the fat remains in the subcutaneous tissue, it poses no health issues; however, if it overflows into other areas, health problems may arise. Approximately 20-22% of people, especially women, may have a predisposition to obesity due to these genetic factors.

Episode #322. Did you know that 30% of cancers are related to obesity? Join me as I sit down with Harvard Professor and endocrinologist Dr Christos Mantzoroz to discuss fatty liver disease, metabolic health, and hormones.

You’ll learn about why so many people are obese and whether you can be overweight and healthy. Dr Mantzoroz breaks down budget-friendly ways to evaluate your metabolic health, explains how hormones affect your weight, and offers his insight on how to treat obesity. Overall, this episode is a masterclass in metabolic health and fatty liver disease.

Specifically, we discuss:

Introduction to The Latest Obesity Research Findings (00:00)
The Evolving Understanding of Obesity Science (03:49)
Uncovering New Fat Storage Mechanisms (10:57)
Modern Techniques for Accurate Body Fat Measurement (15:02)
Why Maintaining Weight Loss Is So Challenging (20:01)
Evolutionary Insights into Human Fat Storage (25:12)
How Leptin Regulates Energy Balance and Health (29:17)
New Approaches to Break Through Weight Set Points (39:27)
Environment's Role in Weight Gain Beyond Diet (45:49)
Decoding the Genetics of Fat Storage and Metabolism (52:59)
Non-Alcoholic Fatty Liver Disease Explained (55:40)
Evidence-Based Nutrition for Optimal Liver Health (01:05:25)
Promising Advances in Non-Invasive Liver Tests (01:10:49)
Oestrogen's Impact on Metabolism (01:20:14)
The Link Between Liver Fat and Insulin Resistance (01:22:04)
Addressing America's Growing Metabolic Health Crisis (01:26:11)
Outro (01:27:11)

Connect with Christos Mantzoros, MD DSc PhD h.c. mult. on LinkedIn, and discover his work here.

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Simon Hill, MSc, BSc (Hons)

Creator of theproof.com and host of The Proof with Simon Hill

Author of The Proof is in the Plants

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