The essence entails the impact of fat distribution on metabolic health, including a liver component where some individuals can have excess fat under the skin but remain metabolically normal. Conversely, severe genetic conditions with absence of subcutaneous fat result in high levels of liver and pancreatic fat, leading to a higher proportion of type 2 diabetes. However, it's not a 100% occurrence as some individuals can store fat without impacting their metabolic health.
Episode #287. Learn about type 2 diabetes from the scientist who has fundamentally changed our understanding of the disease: Professor Roy Taylor. From the twin cycle hypothesis to personal fat threshold, this conversation is an absolute masterclass in what causes type 2 diabetes and the path towards remission for those managing it.
We discuss:
- Introduction to the Twin Cycle Hypothesis & Onset of Diabetes (00:00)
- Delving into the Twin Cycle Hypothesis: Diabetes Aetiology Explained (02:25)
- Risks Associated with High Blood Glucose Levels (14:08)
- Key Factors Causing Insulin Resistance in Muscles (20:53)
- Understanding the Personal Fat Threshold in Diabetes Onset (26:14)
- Assessing the Risk Factors for Developing Type 2 Diabetes (35:07)
- Preventative Measures Against Type 2 Diabetes (41:12)
- Are Conltinuous Glucose Monitors Beneficial for Non-Diabetics? (46:54)
- Investigating the Determinants of Body Fat Distribution (50:15)
- Summary of the DiRECT Trial: Examining the Twin Cycle Hypothesis with Roy Taylor (55:50)
- Effective Strategies for Type 2 Diabetes Remission (1:15:29)
- The Role of Diet Quality in Insulin Sensitivity Improvement (1:28:54)
- Examining the Link Between Protein Consumption and Type 2 Diabetes (1:36:18)
- Incorporating Exercise into Type 2 Diabetes Remission Plans (1:38:31)
- The Possibility of Eradicating Type 2 Diabetes Societally (1:49:03)
- Understanding the Reversal of Type 2 Diabetes: Current Insights (1:52:49)
- Final Thoughts: The Prospects for Diabetes Management (1:56:04)
Learn more about Professor Roy Taylor’s work at go.ncl.ac.uk/diabetes-reversal. You can also read his books, Life Without Diabetes and Your Simple Guide to Reversing Diabetes, for more tools and education.
Optimise your health with InsideTracker’s biomarker analysis. Get exclusive access to InsideTracker’s new ApoB test and a 20% discount on your first order at insidetracker.com/simon.
Enjoy, friends.
Simon
Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants
Watch the episodes on YouTube or listen on Apple/Spotify
Connect with me on Instagram, Twitter, and Facebook
Nourish your gut with my Plant-Based Ferments Guide
Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book
