An expedition of 800 soldiers faced immense challenges in South America, with only 170 surviving due to drowning, disease, hunger, and conflicts with indigenous people. Their misconceptions about the geography of the continent hindered their journey, as they believed they could traverse it like an island. Upon reaching Bogota, they encountered a formidable force of indigenous warriors, led by the most powerful chief in a confederation of chieftains. Despite the potential to overcome the Spanish forces, the indigenous confederation did not crush the invaders, leaving this historical outcome an enduring mystery, in stark contrast to the more contested confrontations in Mexico and Peru.

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