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Unraveling the APOE 4 Gene and the Alzheimer's Puzzle
The Brain Health Revolution Podcast
The Impact of APOE4 on Cholesterol Transport
APOE4 negatively affects the ABCA1 receptor on cell membranes, hindering its ability to transport cholesterol in and out of the cell. This leads to an accumulation of cholesterol inside the cell, causing damage. Understanding the nuanced effects of APOE4, beyond simple classifications of 'good' or 'bad,' is crucial due to its association not only with vascular disease but also with sugar and glycosylation processes. It highlights the complexity of interactions between genetic factors and various physiological mechanisms.
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