Epigenetics plays a critical role in health and aging by potentially preventing issues like cancer through the shutdown of certain genes. It serves as a more accurate measure of biological age than chronological age, as individuals can exhibit significant differences in health despite sharing the same birthdate. Cellular reprogramming, a field focused on reversing aging by reverting cells to their earlier, more primitive states, has shown promising results in animal studies. However, this approach raises concerns about the long-term risk of cancer, emphasizing the evolutionary strategy to guard against cellular misbehavior during critical life stages.
For millennia, humanity has obsessed about halting ageing and, ultimately, preventing death. Yet while advances in medicine and public-health have seen human life-expectancy more than double, our maximum lifespan stubbornly remains around 120 years.
On the latest episode of Nature hits the books, Nobel laureate Venki Ramakrishnan joins us to discuss what scientists have learnt about the molecular processes underlying ageing, whether they can be prevented, and why the quest for longevity also needs to consider the health-related issues associated with old age.
Why We Die: The New Science of Ageing and the Quest for Immortality Venki Ramakrishnan Hodder (2024)
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