*janeway’s thesis and approaching the asymptote *

The significance of Janeway's thesis in 1989 was in laying out the fundamental rules for understanding how the immune system protects the body. This thesis established the concept of pattern recognition receptors which provided a molecular explanation for how the immune system identifies microbes. Despite the thesis operating at a high level above the details, it set the groundwork for further research and understanding. The beauty of this thesis is its aspirational nature, allowing room for elaboration and exploration into the intricate workings of the immune system.