4min snip

The Proof with Simon Hill cover image

Protein Masterclass | Amount, distribution, muscle growth and longevity

The Proof with Simon Hill

NOTE

Optimal protein amount, growth pathways, and the role of rapamycin in longevity

Protein requirements vary throughout life. At midlife, low protein consumption is recommended due to the impact on growth pathways like MTOR and IGF-1. MTOR is important in growth and extends lifespan when suppressed, while IGF-1 regulates growth and its deficiency leads to shorter stature. Rapamycin, a drug that inhibits MTOR, has been shown to significantly extend the lifespan of mice. Experts agree that targeting growth hormone IGF-1 is the top choice for extending human lifespan and health span.

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