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#224 ‒ Dietary protein: amount needed, ideal timing, quality, and more | Don Layman, Ph.D.

The Peter Attia Drive

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Effects of High Protein Diet in Weight Loss Studies

Three distinct studies investigating the impact of high protein diets on weight loss reveal consistent advantages for high protein intake over low protein options. The first well-controlled study showed that, despite identical calorie consumption, participants on a higher protein, low carb diet lost more total weight and fat while preserving lean mass, also benefiting from improved insulin regulation and lower triglyceride levels. This was linked to the thermodynamic effects of protein, which accounted for an estimated daily caloric benefit of around 170 calories for the high protein group. Additional observations indicated that participants on the high protein diet reported lower hunger levels and expressed less need to discuss food or snacks, suggesting enhanced satiety. Furthermore, dropout rates were notably higher in the high carb group over longer study durations, highlighting issues with adherence. Overall, these findings affirm that higher protein diets contribute significantly to weight loss efficacy by preserving lean tissue, enhancing satiety, and possibly providing a thermogenic advantage, advocating for a focus on absolute protein intake rather than percentage of total calories.

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