Science In Action

A record summer temperature in Siberia is an indication of major changes in the Arctic climate. Changing weather patterns there have a knock on effect for other parts of the planet says Climatologist Steve VavrusChile appeared to get Covid-19 under control, but in reality the virus was spreading uncontrollably through poor areas, As we hear from our correspondent in Santiago Jane Chambers, the lockdown has tightened but cases continue to rise.And could mass testing using new saliva tests help control or even end the epidemic? Epidemiologist Julian Peto tells us about his plan which is designed to contain the virus within individual households and stop community spread. Experiments to investigate dark matter have produced some tantalising results, Physicist Laura Manenti says it’s not confirmation of detection, but potentially close. (Image: Rural Scene in Verkhoyansk. Credit: Dean Conger/Corbis via Getty Images)Presenter: Roland Pease Producer: Julian Siddle

A multi arm trial testing a range of drugs has shown that readily available steroids can be lifesaving for people severely ill with Covid-19. Max Parmar, head of the UK Medical Research Council’s clinical trials unit says the trial design, where many potential drugs can be tested against the same controls, is key to producing results quickly. As it spreads around the world SARS-CoV-2 is mutating. But what does this mean? These mutations are part of a natural process and some researchers are finding they make no real difference to patient outcomes so far, but others are concerned the virus may become more dangerous. Neville Sanjana from New York University has been running lab tests on the mutant virus.Measles mutated from an animal virus, developing the ability to jump from cattle to human around 2,500 years ago. Sebastien Calvignac-Spencer from Germany’s Robert Koch Institute tracked its origins using preserved lung samples from centuries old measles victims. Covid -19 has become a magnet for conspiracy theorists. A common unfounded claim is that the virus was deliberately manufactured. During the boredom of lockdown such ideas have taken off online, with conspiracy videos receiving millions of views. We speak to scientists who have been targeted, and become the subject of this online misinformation. (Image: Doctor examines Covid-19 virus patient. Credit: Getty Images)Presenter: Roland Pease Producer: Julian Siddle

Despite the Covid-19 pandemic efforts to counter massive swarms of locusts across East Africa have continued. In many places this has been very effective, killing up to 90% of locusts. However, the threat of repeated waves of locusts remains says Cyril Ferrand, who leads the UN Food and Agriculture Organisation's Resilience Team in East Africa.Conversely West Africa is unaffected by locusts and with a block on imports local producers have seen demand grow for their produce, an unusual positive effect from the pandemic according to Sandrine Dury from the French agricultural research agency CIRAD.We examine the potential for a second wave of coronavirus as many countries relax lockdown measures, businesses reopen and mass protests take to the streets. Epidemiologist Carl Bergstrom is interested in working out which of these movements is likely to have the most impact.And from South Africa, how radio telescope engineers there have turned their hands to developing new ventilators appropriate for regional needs. (Image: Desert locust. Credit: Reuters)Presenter: Roland Pease Producer: Julian Siddle

Autopsies show Covid 19 can affect the brain and other organs. Pathologist Mary Fowkes from the Icahn School of Medicine at Mount Sinai found the signs of stroke - unusually in young people, as well as a disruption of the immune system throughout the body.And studies of heart stem cells show these can be killed by the virus. Cell Biologist Stefanie Dimmeler from the University of Frankfurt says this finding could prove useful in providing treatment and preventative medicine.A massive research project in China has identified over 700 different types of coronavirus carried by bats, some of these obscure virus sequences are thought to have already jumped from bats to human and animals such as pigs. In a similar way to SARS-CoV-2 they present a potential threat as a source of future pandemics says Peter Daszak from the EcoHeath Alliance which conducted the research in collaboration with Chinese scientists. And is there racism in the way people with Covid -19 infections are categorised? It’s an issue which concerns toxicologist Winston Morgan from the University of East London. He says as race is a social construct it’s an inappropriate measure to use when trying to work out who is vulnerable to the virus.(Image: Illustration showing the virus structure of SARS-CoV-2. Credit: CDC HO via AFP / Getty)Presenter: Roland Pease Producer: Julian Siddle

The number of cases of Covid -19 infections in Brazil and deaths related to the pandemic may be much higher than official figures show. Testing of the living is not widespread and there are few resources for analysing the potential role of the virus as a cause of death. Virologist Fernando Spiliki gives us his bleak assessment.A remarkable study from South Africa shows just how easily the virus can spread around a hospital, with a single infected person infecting many. However the route of infection is not necessarily direct person to person transmission says investigator Richard Lessells from the University of KwaZulu Natal. And from London a study in a hospital with many Covid patients at the height of the pandemic supports the South African findings; Researchers found viral particles on surfaces and in the air says Professor Wendy Barclay from Imperial College. An early warning system for outbreaks of the virus or second waves may come from analysis of sewage, Jordan Peccia from Yale University analysed waste from his local sewage treatment works and found peaks in concentrations of the virus in the sludge occurred a few days before increases in hospital admissions.(Image: Supporters of Brazilian President Jair Bolsonaro wear face masks as they demonstrate against quarantine and social distancing measures imposed by governors and mayors to combat the new coronavirus outbreak and demand military intervention. Credit: SERGIO LIMA/AFP via Getty Images)Presenter: Roland Pease Producer: Julian Siddle

There are more than 100 different Covid-19 vaccine trials currently going on. We look at which seem to be the most promising with Helen Branswell from Stat News.And we examine a very old idea, using antibodies from one virus – in this case Sars, to counter another virus Sars-CoV-2 , which causes Covid-19. Davide Corti from Vir Biotechnology says a version of these antibodies offers potential for both vaccination and treatment. Race and Covid-19, there seems to be a link between ethnicity and susceptibility to the virus which can’t be easily explained away by economic factors. That's the finding from a study of nearly six million people in the US conducted by epidemiologist Chris Rentsch from the London School of Hygiene and Tropical Medicine. And social distancing in ancient times, how plagues and pandemics in the past seem to have been defeated using similar behavioural adaptations to those we are current employing. Archaeologist Shadreck Chikure has seen the evidence in sites across Africa.(Image:Vaccine trials Credit: Getty Images) Presenter: Roland Pease Producer: Julian Siddle

How is Covid -19 spread? Who is most at risk and what are the circumstances under which it is most likely to be transmitted? These questions need answers for the implementation of effective and safe strategies to end lockdown. We look at what research is showing. And if you have to go back to work what’s the best way to protect yourself, how should we be using face coverings for example? There are lessons from research on fluid dynamics.Also key is reducing the rate of infection, the R number, Italy relaxed lockdown a few weeks ago we look at early findings on the impact.It’s clear more widespread and effective testing will be needed to reduce transmission, A new test which should be quicker has been developed using synthetic biology and gene editing techniques. (Image: Commuters wear masks whilst travelling on a London Underground train. Credit: Tolga Akmen/Getty Images) Presenter: Roland Pease Producer: Julian Siddle

Research from New York examining the blood of people who have recovered from Covid – 19 shows the majority have produced antibodies against the disease, The researchers hope to soon be able to establish whether this confers long term immunity as with more common viral infections. And Research in Berlin and London has identified biomarkers, minute signs of the disease which may help clinicians identify who is likely to develop severe symptoms and what kind of treatment they might need.Mutations have been much in the headlines, these are a natural processes of evolution and not just in viruses, but the term is misunderstood, two studies focusing on different aspects shed some light on what mutation in SARS-CoV-2 really means. (Image: People wear face masks as they cross a street in Times Square in New York City. Credit: Kena Betancur/AFP via Getty Images)Presenter: Roland Pease Producer: Julian Siddle

Remdesivir a drug eventually rejected as a treatment for Ebola seems to have aided recovery in a trial with more than a thousand Covid -19 patients. Researchers are cautious but hopeful; a leading health official in the US has made comparisons with the impact of game changing drugs used to treat HIV. In contrast an organisation researching the mechanisms by which bat coronaviruses infect humans has had its funding cut following criticism from President Trump.A scheme to help manufacture ventilators and protective equipment worldwide has seen some success with a simple ventilator they developed, now in use in hospitals.And we look at climate change –with this year set for extreme weather(Image: Liberian photographer Alphanso Appleton took this picture of a schoolgirl and sent it to the Wellcome Trust, to express thanks for their and others’ efforts to develop an Ebola vaccine. Credit: Alphanso Appleton/Wellcome Trust)Presenter: Roland Pease Producer: Julian Siddle

President Trump has repeated unfounded claims that scientists created Covid-19 in a lab. Rigorous scrutiny of the genetics of the virus reveals no evidence for such a claim. And Brazil’s President Bolsonaro is at odds with his own health advisors – splitting public opinion and action over lockdown measures needed to control the virus. We also look at why Covid -19 seems to be associated with so many different symptoms, from diarrheal infections to complicating kidney disease, to heart attacks And some potentially good news from HIV research, a new target to stop that virus in its tracks, which might also be useful in the fight against other viruses. (Image: President Trump with Brazilian President Bolsonaro. Credit: Getty Images)Presenter: Roland Pease Producer: Julian Siddle