Science In Action

34 days after it first formed at the far end of the Indian Ocean, record-breaking Cyclone Freddy made a repeat landfall on Mozambique as well as passing over Malawi, causing extensive damage and loss of life. Climate scientists Liz Stephens and Izidine Pinto join Roland to give an update on the destruction and explain how Cyclone Freddy kept going for an exceptionally long time.At the Third International Human Genome Summit in London last week, Professor Katsuhiko Hayashi announced he had created baby mice from eggs formed by male mouse cells. Dr Nitzan Gonen explains the underlying science, whilst Professor Hank Greely discusses the ethics and future prospects.And from one rodent story to another, SARS-CoV-2 has been detected in brown rats scurrying around New York sewers. Dr Thomas DeLiberto from the US Department of Agriculture gives Roland the details.Image credit: Jack McBrams/Getty ImagesProducer: Roland Pease Assistant Producer: Sophie Ormiston

Human Genome Editing: The team meet experts at the Human Genome Editing Summit in London, seeking to cure genetic disease and ensure that it's safe and available to all. Roland Pease hears from Victoria Gray, the first person to be cured of the debilitating and life-shortening disease sickle cell anaemia by gene editing, and from the scientists making it possible. Also, the prospect of work to attempt gene rescue in fetuses before they are born. But the technology is expensive and complex – the question troubling the participants is to ensure people across the world can benefit from it, not just the rich and privileged. And what are the limitations of gene editing? Can it be made more effective, safer? And what of gene edits that will be inherited by future generations?

The long rains of East Africa are forecast to fail again, for the third year running, precipitating a food crisis affecting millions. Science In Action explores the science of the drought, hears about new methods improving forecasts, and what is unusual about the region that makes it so vulnerable.When we think of helium, for many of us balloons and squeaky voices come to mind. But the noble gas is critical for many aspects of modern life – and we’re facing a global shortage. Dr Annie Cheng and her colleagues at the University of Oxford are attempting to solve this by creating a model that has the potential to locate previously untapped reservoirs.Image by Gerald Anderson/Anadolu Agency via Getty ImagesProducer: Roland Pease Assistant Producer: Sophie Ormiston

Cyclone Freddy has made landfall on Madagascar, leaving destruction in its wake. At the time this edition of Science In Action is going to air, Freddy is on course to reach Mozambique and South Africa. Freddy, which has been gaining strength since it originally formed on the 30th of January, is the most powerful southern hemisphere cyclone on record. Professor Francois Engelbrecht provides the science behind the storm system.In the centre of our galaxy, an enormous cloud is heading towards the Milky Way’s supermassive black hole. Dr Anna Ciurlo tells us that this is a unique opportunity to study the influence of the black hole on the cloud’s shape and properties.We’ve heard a lot about balloons floating above Earth recently… but what about sending balloons to Venus? That’s exactly what Dr Siddharth Krishnamoorthy is proposing in order to study Venus’s seismic activity. Recorders on a “floatilla” above the planet’s surface could listen into Venus-quakes and reveal Venus’s mysterious past. And closer to home, scientists have discovered a new layer in the Earth’s core. We journey into the very centre of the Earth with Professor Hrvoje Tkalčić, who tells Roland what the innermost inner core can teach us about our planet’s past.Image: NASA Earth Observatory image by Lauren Dauphin, using VIIRS data from NASA EOSDIS LANCE, GIBS/Worldview, and the Joint Polar Satellite System (JPSS).Producer: Roland Pease Assistant Producer: Sophie Ormiston

In the decade since the genome editing capabilities of CRISPR-Cas9 emerged, research into novel medicines has boomed – but alongside progress comes new ethical considerations. Controversy erupted in 2018, when Chinese scientist He Jiankui created the first babies with edited genomes. After leaving prison last year, he’s now back in the lab trying to raise support for new research but refuses to discuss the ethical implications of his work. Dr Joy Zhang recently arranged a bioethics seminar and invited He Jiankui, it was the first time he’d agreed to engage with a global cohort of CRISPR scientists since returning to his research.Going back in time from cutting-edge to ancient technology, some of the oldest stone tools ever used by human ancestors have been unearthed at a fossil site in Kenya. Professor Tom Plummer talks us through the findings and how important the tools were in our evolution.And we immerse ourselves in the mysterious sounds of the Arctic and Antarctic, from singing ice to the man-made noises of oil and gas drilling. These dramatic soundscapes, created for the Polar Soundscapes project, showcase just how busy our oceans are. Dr Geraint Rhys Whittaker, composer and project lead, believes a novel approach may be required to prompt climate action.Image Credit: Anthony WallacePresenter: Roland Pease Producer: Harrison Lewis Assistant Producer: Sophie Ormiston

In the early hours of Monday, a powerful earthquake hit Kahramanmaras in Turkey. Nine hours later another struck. When this edition of Science in Action first aired, 19,000 people were reported to have died, but that number was expected to rise. Back in 2016, Professor Asli Garagon and her colleagues accurately predicted that an earthquake of this size was coming. Using GPS, they were monitoring the East Anatolian fault to calculate energy building between the plates. With such accurate insight could Turkey have been better prepared?Ross Stein, seismologist and founder of Temblor, a Californian consultancy that specialises in assessing hazard risk, estimates the plates moved at 5,000 mph. The movement of the plates may have built up pressure in other parts of the country. And finally, Tiziana Rossetto, a civil engineer at University College London, knows better than most that earthquakes do not kill, buildings do. She tells Roland how the combination of earthquakes and subsequent aftershocks appear to have even destroyed buildings that were purposely built to withstand them. Presenter: Roland Pease Producer: Harrison Lewis Assistant producer: Sophie Ormiston Image: Aftermath of the deadly earthquake in Gaziantep Credit: REUTERS/Dilara Senkaya

Pull on an extra layer and stay toasty whilst Science in Action braces for a deep freeze. Whilst we know plenty about the ice on the Earth’s poles, Roland is on a chilling journey to see what can be found in deep space. Professor Christoph Salzmann and Professor Andrea Sella at University College London have produced a new phase of ice. Roland heads to the laboratory to see how the usual crystalline ice, found in ice cubes and icebergs, can be broken down and arranged into a new structure. The James Webb Space Telescope has detected the coldest ices to date, deep within a molecular cloud in outer space. Professor Melissa McClure describes how these clouds harbour a variety of different molecules potentially capable of forming the basic building blocks for life. From the edges of the universe to something a little closer to home, Professor Geoff Collins and colleagues have discovered odd tectonic plate activity on icy Europa, one of Jupiter’s moons. And a theory for the origin of life that may surprise you. Professor Philipp Holliger is trying to uncover whether ice played a role in our creation, acting as a medium capable of concentrating molecules and promoting the chemical reactions required for the generation of RNA, essential for cell protein production. Presenter: Roland Pease Producer: Harrison Lewis Assistant Producer: Sophie Ormiston(Photo: Chunk of ice. Credit: Getty Images)

An outbreak of pathogenic bird flu, H5N1, in a Spanish mink farm could be a cause for concern. Some experts fear the virus may now spill over to other mammals without strict surveillance. Marion Koopmans, professor of virology at Erasmus Medical Centre, talks Roland through the potential risks. India’s caste system affects all aspects of society, but how does the hierarchy influence representation of marginalised groups in academia? Science journalist Ankur Paliwal believes that, despite efforts to combat discrimination, not enough is being done, and he has the data to prove it. Imagine a robot... Is it hard, metallic and humanoid? Professor Carmel Majidi from Carnegie Mellon University and his colleagues are thinking outside the robotics box. Their new material, magnetic in nature, can shift between solid and liquid states. It’s even capable of breaking out of robotic jail... And how do echidnas – spiny, long-nosed, egg-laying mammals – manage to stay cool during the hot Australian summers? Image credit: Ole Jensen/Getty Presenter: Roland Pease Producer: Harrison Lewis Assistant Producer: Sophie Ormiston

Climate researcher, Rose Abramoff took to the stage at the American Geophysical Union (AGU) fall meetings, not as a guest speaker but in protest. Whilst her demonstration only lasted 15 seconds, she found her employment terminated from Oak Ridge National Laboratory and research stripped from the AGU programme. She was attempting to persuade other climate scientists to ‘get out of the lab and into the street’. Whilst Rose’s protest hit the headlines in the media, potentially less attention was paid to the session that was taking place at the conference, hosted by Mika Tosca, climate scientist-turn-artist, Associate Professor of Liberal Arts at the School of the Art Institute of Chicago. Roland brings the two together to discuss the event and how climate scientists should approach activism. Although there is no one solution to the climate crisis, Roland loves a brainstorm on Science in Action. Climate activist Stuart Capstick, a Cardiff University psychologist specialising in public attitudes to environmental issues and environmental scientist Robert Young from Western Carolina University take the conversation one step further. Questioning how public perceptions of scientists change when they take evasive action and protest.And finally, we usually hear of seismology reports coming from dense, urban areas prone to earthquakes, delicately perched atop of tectonic plates. But this week, Roland speaks to Professor of Geophysics Zhongwen Zhan from the California Institute of Technology, who’s collecting data from a very unusual place... Image credit: SOPA ImagesPresenter: Roland Pease Producer: Harrison Lewis

Flood warnings in parts of California have seen some of the state’s best known celebrities flee their homes. The current weather conditions are in part the result of ‘Atmospheric rivers’ – literally fast flowing rivers of water vapor in the atmosphere. Marty Ralph from the Scripps Institute has been studying this phenomenon for years, he explains what atmospheric rivers are, and tells us how a greater understanding of the phenomenon is now informing weather forecasting and evacuation plans.Over the past year several million people have fled Ukraine, amongst them many scientists. Nataliya Shulga from the Ukraine Science Club is working on a wide ranging initiative to attract them back. She tells us of plans not just to reconstruct Ukrainian science facilities after the war, but to offer a philosophical change which breaks with the Soviet past - a more global, collaborative environment for scientists returning to the Ukraine. Last December the Afghan Taliban banned women from attending university, its just one of the many moves denying education to women since the Taliban returned to power. Particle physicist Kate Shaw had been working with Afghan physicists in the years before the Taliban’s comeback, she is now developing an initiative with scientists and institutions around the world to offer places to Afghan women keen to study physics. She says institutions and individuals who may be able to help should contact Physics without Frontiers at the International Centre for Theoretical Physics. And Gibbons sing with synchronicity, a new study led by Teresa Raimondi, from the University of Turin shows the ability of couples to chorus together to be rather human like.Image Credit: Josh EdelsonPresenter: Roland Pease Producer: Julian Siddle