The Immunology Podcast

Guest: Dr. Bana Jabri is the Sarah and Harold Lincoln Thompson Professor in the Department of Medicine and the Research Director of the Celiac Disease Center at the University of Chicago. Her research focuses on innate and mucosal immunity, particularly in celiac disease, autoimmune disorders, and inflammatory bowel disease. She talks about the mechanisms of celiac disease and new treatment options. She also discusses how the microbiome can affect immune responses in cancer. Featured Products and Resources: Stay up-to-date with the latest in immune regulation news. Download free immunology wallcharts. The Immunology Science Round Up Capsules to Study the Intestinal Environment – Scientists developed an ingestible device that collects samples from multiple regions of the human intestinal tract during digestion. T Cell Receptor Affinity – Repetitive pathogen exposure leads to the dominant outgrowth of T cell clones with high T cell receptor affinity to the relevant pathogen-associated antigens. Gut Bacterial Evolution Between Species – Analyses of metagenome-resolved genomes from humans and primate species reveal significant co-diversification of bacterial gut symbionts. A Pancreatic Cancer Vaccine – Researchers synthesized mRNA neoantigen vaccines in real time from surgically resected pancreatic ductal adenocarcinoma tumors. Image courtesy of Dr. Bana Jabri Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In May 2023, we attended IMMUNOLOGY2023, the annual meeting of the American Association of Immunologists in Washington, DC, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the final of five special episodes from the meeting. Brenda and Jason talk about sessions on mucosal immunity, emerging pathogens, and having a successful postdoctoral experience. Highlights include Dr. Isaac Chiu‘s talk on pain and mucus production in the gut, Dr. James Crowe‘s talk on monoclonal antibody discovery, and Dr. Amy Hartman’s talk on Rift Valley fever virus. Featured Products and Resources: Read interviews with immunologists. Watch videos on career development from the NIH Office of Intramural Training & Education. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Dive into the intriguing world of immunology, where researchers unveil the role of micelles in drug delivery. Discover how helminth infections may influence susceptibility to SARS-CoV-2. Highlights include investigations on TLR7 and immune cell behavior in juvenile arthritis and newborns. The discussion also explores microbiome effects on immune signaling and groundbreaking cytokine therapies for cancer. Finally, learn about innovative techniques in targeted immunotherapy and the pivotal role of regulatory T cells in minimizing allograft rejection.

Dr. Anthony Fauci, a leading immunologist renowned for his COVID-19 response, shares insights on the pandemic's lessons. Dr. Doug Green, an authority on T cell activation, discusses critical dynamics of T cell behavior. The conversation dives into immune challenges posed by aging and obesity, along with innovative strategies for enhanced cancer vaccines. Listeners can expect to gain a deeper understanding of T cell function and the importance of genetics in immune responses. Exciting advancements in immunology are also unveiled!

In May 2023, we attended IMMUNOLOGY2023, the annual meeting of the American Association of Immunologists in Washington, DC, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the second of five special episodes from the meeting. Brenda and Jason discuss sessions on peripheral neuroimmune interactions and tumor cellular therapy. Highlights include the President’s Address by Dr. Mark Davis and Dr. Barbara Rehermann’s presentation on wild mouse microbiota. Featured Products and Resources: Explore STEMCELL Technologies’ workshops and resources at IMMUNOLOGY2023 Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In May 2023, we attended IMMUNOLOGY2023, the annual meeting of the American Association of Immunologists in Washington, DC, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the first of five special episodes from the meeting, in which Jason and Brenda summarize symposia on B and T-helper cells, and metabolic and gut microbiota. They discuss antigenic imprinting, lupus immunophenotyping and sex differences, dengue vaccines, and cytomegalovirus research. Featured Products and Resources: Explore STEMCELL Technologies’ workshops at IMMUNOLOGY2023 Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Prasanna Jagannathan is an Assistant Professor of Medicine in Infectious Diseases and of Microbiology and Immunology at Stanford University. His research focuses on the mechanisms of clinical immunity to malaria. He talks about how repeated exposure to malaria can lead to tolerance without symptoms, promising vaccines and treatments to prevent reinfection, and the role of innate immune cells. He also discusses shifting from religious studies to teaching to medicine, and establishing long-term collaborations with researchers in Uganda. Featured Products and Resources: We’ll see you at IMMUNOLOGY2023! Keep current with the latest immunology of infectious diseases news. The Immunology Science Round Up Blocking Psoriasis Signaling with Methotrexate – Scientists identified SLC46A2 as an important target for anti-inflammatory intervention in the skin. Tumor-Infiltrating Tregs – Researchers discovered and validated new master regulators of human tumor-infiltrating Tregs. TH9 Cells and Allergic Inflammation – JAK inhibitors may be effective for allergic patients with TH9 cell expansion. Gene Editing Primary Lymphocytes – Researchers used a CRISPR ribonucleoprotein mixed with an amphiphilic peptide to increase the yields of edited primary human lymphocytes. Peptide-Assisted Genome Editing – Scientists demonstrated rapid and efficient editing of primary cells with low cellular toxicity and no significant transcriptional perturbation. Image courtesy of Dr. Prasanna Jagannathan Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Joshua Brody is the Director of the Lymphoma Immunotherapy Program at the Tisch Cancer Institute at Mount Sinai. The Brody lab studies basic and applied tumor immunology for the development of cancer immunotherapies, particularly for lymphomas and melanomas. He talks about dendritic cells to improve oncolytic virus immunotherapy and in situ vaccination to improve PD-1 blockade responses. Featured Products and Resources: IMMUNOLOGY2023 will be held May 11-15 in Washington, DC. Register now! T Cell Therapy Research: From Bench to Bedside The Immunology Science Round Up Enhancing T Cell Immunity to SARS-CoV-2 Variants – A new mRNA vaccine component elicits non-spike T cell responses in mice while maintaining spike immunity. Why Infants Are Protected from Pneumonia – Enhanced opsonophagocytosis by neonatal neutrophils improves protection against Streptococcus pneumoniae in early life. Tertiary Lymphoid Structures and Lung Cancer Immunotherapy – Researchers identified endogenous retrovirus envelope glycoproteins as a dominant antitumor antibody target in lung cancer. Engineered Bacteria As a Melanoma Vaccine – Scientists engineered a Staphylococcus epidermidis strain to express melanoma tumor antigens and tested their ability to drive antitumor immune responses. Image courtesy of Dr. Joshua Brody Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: Dr. Doug Green is the Peter C. Doherty Endowed Chair of Immunology at St. Jude Children’s Research Hospital. His research focuses on the central mechanisms of cell death, survival, and the immune response. He talks about what happens when cell death fails, the role of Myc, and setting up collaborations in science. Featured Products and Resources: Register for IMMUNOLOGY2023 Watch a Free Webinar on Best Practices and Innovative Technologies for T Cell Therapy Research. The Immunology Science Round Up Gut Bacteria and Social Avoidance – Colonic γδ T cells modulate behavioral vulnerability to chronic social stress via dectin-1 signaling. Base Editing to Treat Severe Combined Immunodeficiency –  Researchers used an adenine base editing strategy to restore CD3δ in autologous hematopoietic stem and progenitor cells. FcμR–IgM Interaction – Scientists used crystallography and cryo-electron microscopy to study how FcμR recognizes different forms of IgM to regulate diverse immune responses. Tissue-Resident Macrophage Differentiation – Researchers analyzed immune cells in the pleural cavity of C57BL/6 and BALB/c mice and found different responses to nematode infection. Image courtesy of Dr. Doug Green Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guests: Dr. Miriam Merad is the President & Scientific Programme Committee Co-Chair of the International Union of Immunological Societies (IUIS) and Dr. Mark Davis is the Scientific Programme Committee Chair. They talk about what to expect at the 2023 IUIS Congress being held November 27 – December 2 in Cape Town, South Africa. They discuss hosting the meeting in Africa, the importance of infectious disease research and international collaborations, and the highlights of this year’s program. Featured Products and Resources: Attend IMMUNOLOGY2023 May 11-15 in Washington, DC! Prepare for your next conference with this toolkit. The Immunology Science Round Up PD-L1 and Myeloid Signaling – PD-L1 promotes metastatic, but not primary, tumor growth via a cytotoxic T lymphocyte-dependent mechanism. T Cell Responses to SARS-CoV-2 – Researchers used “spheromer” peptide MHC multimer reagents to analyze T cell responses to SARS-CoV-2 infection and vaccination. ER Stress Promotes Th17 Differentiation – ER stress in intestinal epithelial cells drives gut Th17 differentiation. How Sucralose Affects T Cells – High doses of sucralose in mice results in immunomodulatory effects by limiting T cell proliferation and T cell differentiation.deling and two melanoma patients. Image courtesy of Drs. Miriam Merad and Mark Davis Subscribe to our newsletter! Never miss updates about new episodes. Subscribe