Dr. Dario Vignali discusses T cell regulation in cancer and autoimmunity. Highlights include dual targeting CAR T cells in leukemia, optimal vaccine dosing strategies, IL-33's role in macrophage metabolism, and T cell regulation and metabolism in immune function. The episode also explores brewing beer as a scientist's escape during COVID.

Dr. Anil Bhushan, expert in immune response to senescent cells, discusses topics such as natural resistance to SARS-CoV-2, new cancer immunotherapy targets, and immune escape in colorectal cancer. The podcast explores the impact of OAS1 prenylation on COVID-19 severity, differences in immune responses in colorectal cancer tumors, and challenges in drugging cellular targets. It also covers harmful effects of senescent cells, selective depletion in adipose tissue using INKT cells, and promotes opportunities for postdoctoral fellows in science.

Dr. Michael Burton discusses the immune-brain-neuron axis impacting pain and immune responses. Topics include nanoparticle vaccines for COVID, advancements in immunotherapy, neuroimmunology research, and the interaction between the nervous and immune systems.

Dr. Frances Lund discusses B-cell roles, nasal vaccines for respiratory illnesses, and immune response modulation. Topics include COVID vaccine design, T-cell cancer vaccines, stress impact on immunity, sexual dimorphism, and intranasal vaccine development.

Dr. Jeffrey Bluestone of Sonoma Biotherapeutics discusses creating cell therapies for autoimmune diseases. Topics include neutrophil ferroptosis in lupus, T cell responses to mRNA vaccines, and the role of T regulatory cells in immunology.

Dr. Christopher Klebanoff discusses adoptive T cell transfer for solid tumors, targeting T-regulatory cells with a unique molecule, understanding environmental enteric dysfunction in mice, and the impact of maternal immune cells on neonatal immunity. He also shares insights on T-cell immunotherapy, MDs entering immunology research, and advancements in adoptive T cell transfer for cancer therapy.

Dr. James Crowe, Director of the Vanderbilt Vaccine Center, discusses COVID-19 vaccine efficacy against the Delta variant, T cell specificity in melanoma, overcoming PD-1 blockade resistance in lung cancer, and advancements in antibodies for viral pathogens. He also explores transitioning from academia to starting a biotech company and the importance of good manufacturing practices in biotech.

Explore the intricate world of lymphocyte activation with Dr. Marc Jenkins, focusing on CD4+ T and B cell activation. Topics cover metabolic control of T follicular helper cells, the impact of HIV treatment on microbiome, rare side effects of COVID-19 vaccines, the role of CD28 activation in T cell response, and the challenges in studying CD4 T cells. Dr. Jenkins also shares insights into TCR signaling, T cell differentiation, and his outdoor adventures in fishing and biking.

Dr. Robyn Hall, a veterinary virologist, discusses using rabbit caliciviruses for biocontrol. Topics include antimicrobial response networks in leprosy, T cell roles in cancer, rabbit impact on Australia, ethical concerns of virus use, and studying rabbit virus evolution through organoid models.

Dr. Isaac Chiu, an expert on nervous system and inflammation, teams up with Dr. Tiphaine Voisin, a neuro-immunology specialist, to explore the fascinating world of itch. They delve into the complex relationship between sensory neurons and immune responses, revealing how leukotriene pathways trigger scratching behavior. The duo also discusses innovative therapeutic targets, including monoclonal antibodies, and the joy of blending science with personal creativity. Their insights shine a light on chronic itch and the potential for novel treatments.