Driving Alpha

What if the biggest venture opportunities aren’t in the next SaaS tool, but in the markets everyone avoids? Salen Churi, founder and general partner at Trust Ventures, is proving that regulation-heavy industries hold the keys to outsize alpha. A former law professor turned VC, Salen helps startups turn red tape into competitive edge.   Here’s a glimpse of what you’ll learn: 00:40 Introduction to Driving Alpha Podcast 01:58 Salen Churi’s Background and Family History 03:30 The Intersection of Innovation and Regulation 05:41 Founding Trust Ventures 12:29 Case Studies: Oklo and ICON 17:05 Navigating Regulatory Challenges 22:03 Investing in Regulatory Risk 25:27 Unique Approach to Venture Capital 26:35 Policy Partner and Regulatory Strategy 26:57 Investment Strategy in Nuclear and Competitive Markets 28:46 Innovative Solutions in the Energy Sector 30:44 The Role of Batteries in Grid Management 38:46 AI and Regulatory Challenges 43:48 Future Vision and Regulatory Changes 46:28 The Importance of Tackling Regulatory Problems   In this episode,  Salen Churi breaks down how Trust Ventures consistently finds billion-dollar potential hiding in plain sight, by backing companies that challenge outdated regulatory systems. From modular nuclear energy to 3D-printed homes and AI-driven battery grids, Trust helps founders reshape broken systems and unlock massive, underserved markets. Salen explains why regulation isn't a red flag, it's often the moat. He shares stories from Trust's early bets like Oklo, ICON, and Base Power, each tackling entrenched incumbents with bold tech and smart policy strategy. He also dives into how Trust evaluates regulatory risk, why they're not afraid of government-adjacent challenges, and how their model as a “policy partner” is turning underdog startups into market leaders. Whether you're a founder eyeing a legacy industry or a VC seeking differentiated returns, this episode is a playbook for turning policy gridlock into venture-scale alpha.

Can a PhD in accounting build a top-tier VC firm in the heartland, and beat the coastal giants?  Ira Weiss did just that. As founding partner of Hyde Park Venture Partners and a professor at Chicago Booth, Ira has quietly helped turn the Midwest into a serious startup engine, backing breakout companies like ShipBob and Audit Site before they were household names. Here’s a glimpse of what you’ll learn: 00:48 Introduction to Driving Alpha 01:00 Guest Introduction: Ira Weiss 01:14 Ira's Academic and Professional Journey 01:50 Hyde Park Venture Partners 03:07 Personal Connection and University of Chicago 05:00 Transition to Venture Capital 06:25 Routes to Becoming a Venture Capitalist 08:51 Evaluating Startups: Then and Now 12:23 Case Study: ShipBob 18:32 The Importance of Sticky Products 19:34 Exciting New Ventures: Audit Site 22:46 AI's Role in Auditing and Financial Systems 24:31 AI Adoption in Companies and Investment Strategies 28:45 AI's Impact on Academia and Student Learning 31:45 Investment Decision-Making Processes 38:06 Midwestern Entrepreneurship and Investment Insights 42:01 Reflections and Closing Remarks   In this episode, Ira shares how his journey from academia to early-stage venture capital gave him a unique lens for spotting high-potential founders in overlooked markets. He dives into the importance of founder chemistry, sticky products, and the traits that separate real moats from hype. You'll hear how ShipBob scaled in a gritty, unsexy market and how Audit Site is transforming the world of financial audits using cutting-edge tech. We also explore how AI is reshaping the startup world, from reducing headcount to disrupting traditional B2B models, and what that means for investors. Ira offers tactical advice for aspiring VCs, insights into how investment committees really work, and why the next breakout startup might not be in San Francisco or New York.  

Brad Feld isn’t just a name in venture capital; he’s one of the architects behind the startup ecosystem as we know it. From launching Techstars to mentoring hundreds of founders and fund managers, his legacy is rooted in building, not boasting. Here’s a glimpse of what you’ll learn: 00:48 Introduction to Driving Alpha 01:38 Brad Feld's Journey and Achievements 03:38 Reflections on Life and Career 05:51 The Future of Foundry Group 08:02 Mentorship and Its Impact 10:52 Influential Mentors in Brad's Life 15:17 The SoftBank Connection 23:29 Star Wars vs. Star Trek 27:58 Analog Analog and Investment Insights 30:31 The Evolution of Ticketing Platforms 30:51 AI in Customer Support 31:31 Personal Coding Journey 32:14 Comparing AI Models: Claude vs. OpenAI 35:09 Investment Dynamics in Tech 36:17 The Economics of Ride-Sharing 38:17 The Future of AI-Powered Tools 41:30 Challenges in Venture Capital 54:22 Reflections on Venture Capital   In this episode, Brad joins Steve Brotman of Alpha Partners for a wide-ranging conversation on investing through downturns, the rise of AI-powered tooling, and what it truly means to give first. Brad explains how his thinking evolved across three decades, from early wins to long-tail fund management, and how he's now channeling his energy into mentorship, writing, and second-order impact. He opens up about his “third third” philosophy of life, lessons from working with SoftBank in the dot-com era, and why today’s founders can’t afford to chase hype. Brad also shares his hands-on experience using tools like Cursor and Claude, drawing unexpected parallels between AI and the early internet. This is more than a look back; it’s a roadmap for what’s ahead. Want more of Brad’s wisdom? Grab his latest book:  Give First: The Power of Mentorship,  a must-read for founders, fund managers, and anyone shaping the future of innovation.

What happens when a Google and Facebook engineering leader turns his focus to helping immigrant founders dominate in AI and robotics?  Ihar Mahaniok, Founder and Managing Partner of Geek Ventures, has invested in over 100 startups, including five unicorns, and is now channeling his experience into backing the next generation of world-changing entrepreneurs. Here’s a glimpse of what you’ll learn: 00:41 Welcome to Driving Alpha Podcast 00:51 Meet the Guest: Ihar Mahaniok of Geek Ventures 01:38 Ihar's Journey: From Coding to Angel Investing 03:26 Building Geek Ventures: Focus on Immigrant Founders 03:42 Navigating the US as an Immigrant Entrepreneur 04:58 The Power of Networking and LinkedIn 12:15 Geek Ventures' Unique Approach to Investing 20:36 Challenges Immigrant Founders Face in the US 22:54 The Future of AI and Its Impact 29:46 Building Efficient Teams in Startups 37:48 Advice for Aspiring VCs and Founders 40:57 Conclusion and Final Thoughts   In this episode, Ihar reveals how his own immigrant journey shaped his mission to close the opportunity gap for founders arriving in the U.S. without deep networks. He shares the traits that make immigrant entrepreneurs uniquely equipped to win—grit, ambition, and fresh perspectives—and explains how Geek Ventures provides the capital, connections, and strategic support to accelerate their success. The conversation explores the evolving landscape of AI and robotics, why small, elite teams often outperform larger ones, and how cultural differences influence fundraising strategies. Ihar also unpacks his framework for spotting exceptional founders early, building defensible moats beyond technology, and preparing for a future where AI will create more unicorns than ever before. Whether you’re a founder, investor, or AI enthusiast, this episode delivers actionable insights on scaling bold ideas into lasting impact.  

What happens when decades of media and venture capital experience converge? Stewart Alsop, co-founder of TK MediaTech Ventures and a VC since 1996, brings a journalist’s clarity and an investor’s vision to the evolving landscape of media technology. Here’s a glimpse of what you’ll learn: 00:48 Introduction and Guest Welcome 01:02 Early Career and First Impressions 01:37 Bluntness and Career Challenges 03:00 Investment Philosophy and Media Tech Focus 06:45 The Third Convergence of Media and Technology 16:20 AI and Media Tech Investments 23:56 Finding the Right Entrepreneurs 25:27 Conclusion and Final Thoughts   In this episode, Stewart joins Brian Smiga to explore the “third convergence” of media and technology, an era defined by high-fidelity digital twins, immersive media, and AI-powered creativity. He unpacks how this new phase builds on two prior tech-media inflection points and why his firm, TK MediaTech Ventures, is poised to capitalize on this transformation. The conversation dives into Stewart’s investment philosophy, the value of blunt honesty in venture partnerships, and the thesis behind faster time-to-liquidity in media tech. From the early bets on TiVo and Twitch to today’s frontier in digital avatars and real-time reality rendering, Stewart explains what founders and LPs should know and why the next media revolution may already be here.  

Renata Quintini and Roseanne Wincek are the powerhouse duo behind Renegade Partners, a venture firm purpose-built to guide startups through the critical "teenage years" of growth. With prior roles at Felicis, Lux, Canaan, and IVP, they’ve helped scale some of today’s most iconic companies and are rewriting the playbook on early-stage investing. Here’s a glimpse of what you’ll learn: 00:48 Welcome to Driving Alpha Podcast 00:59 Meet Renata Tini and Roseanne Ek 01:49 Renata's Journey: From Law to Venture Capital 09:20 Roseanne's Path: From Science to Venture 15:36 The Birth of Renegade Partners 18:35 Challenges and Strategies in Building a Fund 21:30 In-Person vs. Zoom: The Debate 23:10 Fundraising Challenges and Market Dynamics 26:30 Renegade Partners' Hands-On Approach 33:43 Evaluating Companies with Decision Science 36:50 Trends and Changes in Venture Capital 42:24 Navigating the AI Investment Landscape 46:40 Final Thoughts and Contact Information   In this episode, Renata and Roseanne break down how they’ve built Renegade Partners from the ground up, bringing a hands-on, decision science-driven approach to Series A investing. They share how their careers, spanning law, science, and venture capital, shaped a uniquely structured model focused on depth, not breadth, when working with founders. You’ll hear their behind-the-scenes story of launching a fund just days before the COVID lockdown, navigating market corrections, and building deep trust with LPs. From boardroom dynamics to AI diligence, they offer hard-earned insights into backing durable businesses in a noisy market. Whether you're a VC, operator, or founder, this conversation is packed with lessons on firm building, founder support, and strategic conviction.  

Francisco Gimenez, Partner at 8VC, shares his unconventional journey from Stanford PhD to venture capital, where he leads investments in Bio-IT and enterprise AI. Known for his technical background and sharp instincts, Francisco has been pivotal in backing startups pushing the boundaries of biotech and healthcare innovation.   Here’s a glimpse of what you’ll learn: 00:48 Introduction to Driving Alpha 01:18 Meet Francisco Gimenez: A Journey from Academia to Venture Capital 02:45 Francisco's Early Career and Academic Background 04:02 Joining Formation Eight and Transition to 8VC 06:18 Investing in Visionary Founders and Unique Companies 08:26 Challenges and Insights in Deep Tech and Biotech Investing 12:15 The Importance of Problem-Oriented Founders 19:51 Exciting Companies and Future Prospects 20:41 Engineering Principles in Biologics 22:26 Innovative Cell Biology Tools 23:36 Biological Foundation Models and AI 24:52 VC Perspective on Biotech and Pharma 26:00 Challenges in Biotech Innovation 33:50 NIH Funding and Indirect Costs 39:13 Advice for Aspiring VCs and Founders 42:20 Conclusion and Final Thoughts   In this episode, Francisco unpacks how he spots the kinds of biotech companies others overlook, those “end-of-one” startups tackling massively complex problems with groundbreaking approaches. He explains why he focuses on founders driven by a deep obsession with solving difficult problems, rather than chasing trends or easy wins. The discussion explores the future of biotech, with insights into companies like Big Hat Biosciences and Seleno Therapeutics, pioneers at the intersection of AI and biology. Francisco explains why applying engineering and iterative design principles to the life sciences is unlocking new frontiers in drug development. He also offers his take on NIH funding controversies and shares why decentralized biotech innovation could spark the next wave of transformative therapies.  

Ben Orthlieb, co-founder of Blue Moon and former LinkedIn and Emergence star, is transforming venture capital with AI and behavioral science. He discusses how Blue Moon identifies top founders and predicts billion-dollar potential through innovative evaluation methods. With proprietary AI agents, they analyze thousands of startups yearly, focusing on true founder potential rather than traditional metrics. Ben outlines their unique two-meeting investment process and emphasizes the importance of small checks to foster entrepreneurial innovation.

What if the key to outsized venture returns isn’t just a great idea but the unshakable resilience of the founder behind it? Jonathan Taylor and Brice Penaud of Water Bear Ventures believe grit is the ultimate differentiator, and they’ve built a fund around finding it. Jonathan brings years of experience driving strategic outcomes in venture, while Brice draws on a behavioral science background to decode the mindset of top-tier founders. Here’s a glimpse of what you’ll learn: 00:00 Introduction to Driving Alpha 00:43 Meet the Water Bear Team 02:15 The Origin of Water Bear Ventures 05:29 Defining Exponential Value 08:19 Art Meets Science in Early-Stage Investing 11:06 Building Relationships and Measuring Grit 16:44 Hunting Grounds for Gritty Founders 18:40 Involvement Beyond Capital 23:14 Lessons from Fund One and Plans for Fund Two 32:49 Optimizing LP Relationships 37:52 Future Vision for Water Bear Ventures 40:47 Conclusion and Final Thoughts   In this episode, Host Sam Silvershein sits down with the Water Bear Ventures team to explore how they invest in adaptability, grit, and long-term value creation at the earliest stages. From the origins of their firm’s name to the behavioral cues they use to identify resilient founders, Jonathan and Brice reveal the real mechanics of building a differentiated early-stage portfolio. You’ll hear how Water Bear's founder-first, anti-hype approach helped them outperform with Fund I and how those lessons are shaping their strategy for Fund II. They also break down how they build trust with LPs, support founders beyond capital, and maintain focus in a landscape full of distractions. If you want a deeper understanding of what makes early-stage investing work, this conversation delivers.  

What does it take to turn early traction into scalable momentum? And how do you know if your startup—and your engine—is even built for venture capital? Here’s a glimpse of what you’ll learn: 00:43 Introduction to Driving Alpha Podcast   02:20 Meet Manishh Patel: From Google to Nava Ventures   03:17 Growing Up in Rural Kentucky   05:24 The Journey to Venture Capital   08:17 Founding Nava Ventures   16:22 The Series A Focus   19:57 Building the Flywheel: Operational Infrastructure   20:41 Refining the Business Model   22:30 Hiring and Team Dynamics   22:52 The Importance of Closing Learning Loops   25:07 The Role of Venture Capital in Building Companies   28:22 Advice for Founders on Raising Venture Capital   35:07 Vetting Venture Capitalists   38:31 Final Thoughts and Contact Information In this episode, Host Zoe van den Bol sits down with Manish Patel, managing partner at Nava Ventures, for a candid and insightful conversation on what really matters at the Series A stage. Manish shares his journey from rural Kentucky to Google PM, to building Nava Ventures into one of the most focused Series A firms in the game. With lessons drawn from his operating days and years of backing breakout companies, this is a must-listen for founders, investors, and anyone building in early-stage tech. They also discussed why Series A is the most critical inflection point for a startup, how to build a real “flywheel” for growth, and when venture capital acts like fuel—or becomes a liability. Manish also shares what he looks for in founders, how Nava’s high-conviction, low-velocity model gives them an edge, and the key signals that differentiate enduring companies from fast, flashy ones.