Dr Paul Young describes MEGA-ROX, a registry-based, adaptive platform trial investigating oxygenation targets in the critically ill. This is followed by a panel discussion involving trialists, methodologists and statisticians on this ambitious trial design.

Dr Paul Young (Wellington, New Zealand) presents the ICU-ROX trial, investigating conservative oxygen therapy in mechanically ventilated patients in the ICU, at the Critical Care Reviews Meeting 2020, in Titanic Belfast. Prof Anders Perner (Copenhagen, Denmark) gives an editorial on this trial afterwards.

Prof Kathryn Maitland delivers the honorary John Hinds Lecture, entitled "A Higher Calling: two decades of emergency research in Africa", at the Critical Care Reviews Meeting 2020, at Titanic Belfast.

Prof Kathryn Maitland discusses the TRACT trial, investigating red blood cell transfusion in African children with anaemia, at the Critical Care Reviews Meeting 2020, at Titanic Belfast.

Prof Maureen McCunn delivers the annual honorary John Hinds Trauma Lecture at the Critical Care Reviews Meeting 2019, in Titanic, Belfast, entitled "A Culture of Excellence - The R Adams Cowley Shock Trauma Center"

Dr Lennie Derde delivers an editorial on the PreVENT trial, comparing low with intermediate tidal volumes in critically ill patients without ARDS, at the Critical Care Reviews Meeting 2019, in Titanic, Belfast.

Prof Marcus Schultz presents the PreVENT trial, comparing low with intermediate tidal volumes in critically ill patients without ARDS, at the Critical Care Reviews Meeting 2019, in Titanic, Belfast.

Prof Maureen McCunn delivers an editorial on the PAMPer trial, investigating plasma in prehospital trauma, at the Critical Care Reviews Meeting 2019, at Titanic, Belfast.

Prof Jason Sperry presents the PAMPer trial, investigating plasma in prehospital trauma, at the Critical Care Reviews Meeting 2019, at Titanic, Belfast.

Prof Marion Campbell delivers an editorial on the EOLIA trial, investigating ECMO in severe ARDS, at the Critical Care Reviews Meeting 2019, in Titanic, Belfast.