Tick Boot Camp

Dr. Geoff Dow, CEO of 60 Degrees Pharmaceuticals and former malaria drug developer at Walter Reed, joins the Tick Boot Camp Podcast to unpack the science and strategy behind treating babesiosis. Drawing parallels to malaria, Dow explains why tafenoquine (brand: Arakoda), FDA-approved for malaria prevention, is being studied for Babesia, how coinfections (Borrelia, Bartonella) complicate care, and why chronic illness needs a different clinical approach. He previews an upcoming Mount Sinai trial for chronic babesiosis focused on fatigue outcomes and discusses real-world diagnostics using FDA-approved blood donor screening plus PCRs from Galaxy Diagnostics and Mayo Clinic. The conversation also touches on prophylaxis concepts, immune dysregulation, and building a clearer path from anecdote to evidence for the tick-borne disease community. Guest Geoff Dow, BSc, MBA, PhD CEO & Board Member, 60 Degrees Pharmaceuticals Background: Biotechnology (Perth, Australia), PhD in malaria drug discovery, decade at Walter Reed Army Institute of Research, MBA in the U.S. Leads clinical programs exploring tafenoquine for babesiosis. Key Topics & Takeaways Malaria ↔ Babesiosis Parallels: Both are red-blood-cell parasites; acute symptoms driven by red cell destruction. Similar drug targets justify testing some anti-malarials against Babesia. Why Tafenoquine (Arakoda): An 8-aminoquinoline that induces oxidative stress in RBCs; distinct mechanism from atovaquone + azithromycin combo (current standard for acute babesiosis), potentially useful for resistance management. Chronic vs. Acute Disease: Acute babesiosis in immunocompetent patients often responds to standard care; chronic illness remains under-defined and underserved. Coinfections Are Common: Many chronically ill patients present with Borrelia, Bartonella, and Babesia together; diagnostics and treatment need to acknowledge polymicrobial reality. Upcoming Clinical Trial (Mount Sinai): Population: Chronic babesiosis with disabling fatigue, plus Babesia symptoms (e.g., air hunger, anemia) and lab evidence in the last 12 months. Regimen: 4-day loading dose then 200 mg weekly of tafenoquine for 3 months. Outcomes: Patient-reported fatigue (quality-of-life) + monthly molecular testing (FDA blood donor test, Galaxy Diagnostics PCR, Mayo Clinic PCR) during treatment and 3 months post-therapy. Goals: Demonstrate symptom improvement, assess eradication signals, and validate accessible diagnostics against an FDA-accepted assay. Prophylaxis & Post-Exposure Ideas: Animal data suggest short-course tafenoquine can eradicate early Babesia; human prophylaxis trials face feasibility and regulatory hurdles. Diagnostics Gap: Need for standardized, sensitive tools to define chronic babesiosis and track response. This trial also serves as a real-world diagnostic comparison. Immune Dysregulation & IACI: Overlap among long COVID, ME/CFS, post-treatment Lyme—shared theme of immune dysregulation with possible persistent antigen stimulation. Safety Notes: G6PD deficiency is relevant to 8-aminoquinolines; established safety database exists for malaria prevention dosing—critical as studies expand to babesiosis. Notable Quotes “You’ve got to put some lines in the sand—run the trial, collect data, and move the field forward.” “The best we can do for chronic disease starts with defining it—and validating the diagnostics we use to track it.” “8-aminoquinolines offer a different mechanism than current babesiosis standards—key for resistance and combinations.” Resources Mentioned Arakoda (tafenoquine): FDA-approved for malaria prevention; under study for babesiosis. Diagnostics: FDA-approved Babesia blood donor screen; Galaxy Diagnostics PCR; Mayo Clinic PCR. Organizations & Events: ILADS, Global Lyme Alliance, tick-borne disease conferences. Research Partners: Mount Sinai (NYC), Tulane University (Bartonella/Borrelia collaboration). Who Should Listen Patients with chronic Lyme or chronic babesiosis symptoms (fatigue, air hunger, anemia) Clinicians seeking updates on Babesia treatment research and diagnostics Caregivers and advocates tracking IACI and immune dysregulation science Researchers exploring antimalarial repurposing for tick-borne diseases Call to Action Subscribe to Tick Boot Camp and share this episode with someone navigating chronic tick-borne illness.

In this special Tick Boot Camp Podcast episode recorded live at Project Lab Coat during New York Fashion Week (NYFW), we sit down with Colonel Nicole Malachowski, USAF (Ret.). Col. Malachowski, the first female pilot of the USAF Thunderbirds and a Lyme patient advocate, walked the runway with us at Project Lab Coat and served as the sole patient representative on the National Academies of Sciences, Engineering, and Medicine committee that authored the landmark report on Lyme infection-associated chronic illness (Lyme IACI). She shares her perspective on why this recognition is a historic milestone for the Lyme community. What You’ll Learn in This Episode Why the term Lyme IACI (infection-associated chronic illness) matters and how it creates an inclusive umbrella for persistent symptoms after Lyme infection. How the National Academies report represents the first time the U.S. government has officially recognized Lyme IACI. What it was like for Col. Malachowski to serve as the sole patient representative on the committee alongside scientists and clinicians. Why the report calls for running treatment trials in parallel with biomarker discovery so patients are not left waiting. How collaboration with long COVID and ME/CFS communities can accelerate solutions and strengthen advocacy. The role of AI and machine learning in analyzing patient data, biobanks, and surveys to identify new diagnostics and repurposed therapies. Why visibility at NYFW Project Lab Coat signals growing mainstream recognition of Lyme disease. About Col. Nicole Malachowski Col. Malachowski is a retired U.S. Air Force fighter pilot, the first woman selected to fly with the USAF Thunderbirds, and a National Women’s Hall of Fame inductee. After contracting a tick-borne illness and being medically retired, she became a nationally recognized speaker and advocate for Lyme patients. She served as the sole patient voice on the National Academies committee that authored the landmark report on Lyme IACI, commissioned with support from the Steven & Alexandra Cohen Foundation. About Project Lab Coat at New York Fashion Week Project Lab Coat was a groundbreaking event held on September 13, 2025, during New York Fashion Week (NYFW). The show brought together prominent celebrities, researchers, doctors, and advocates who were invited to walk the runway to spotlight Lyme disease and raise funds for Lyme disease research. For the first time, the global visibility of NYFW was used to highlight one of the fastest-growing infectious diseases in the world. Tick Boot Camp co-founders Matt Sabatello and Rich Johannesen, together with Dr. Tal, walked the runway at Project Lab Coat, joining leaders from medicine, science, entertainment, and advocacy. Project Lab Coat demonstrated the power of mainstream platforms to bring awareness, credibility, and resources to the fight against Lyme disease. Key Takeaways Federal recognition matters – Lyme IACI in a National Academies report marks a turning point in credibility and urgency. Patients at the center – clinical trials must include patients from design through reporting. Collaboration is key – linking Lyme, long COVID, ME/CFS, and other infection-associated conditions strengthens progress. Do both now – pursue biomarkers and cures while also running treatment studies to help patients immediately. Technology accelerates hope – AI and machine learning can unlock insights from existing patient data. Resources and Links Read the full National Academies of Sciences, Engineering, and Medicine report on Lyme IACI Read our recap of Project Lab Coat at New York Fashion Week (NYFW)

In this special Tick Boot Camp Podcast episode recorded live at Project Lab Coat during New York Fashion Week (NYFW), we sit down with Dr. Michal “Mikki” Caspi Tal, Principal Scientist in the Department of Biological Engineering at MIT and Associate Scientific Director of the MIT Center for Gynepathology Research. Dr. Tal is an immunologist and immunoengineer whose groundbreaking research focuses on the connections between infections and chronic diseases, including Lyme disease and long COVID. At her Tal Research Group lab, she studies why some people recover quickly after infection while others develop chronic illness, with a focus on the immune system’s different responses in men and women. What You’ll Learn in This Episode How Dr. Tal’s lab uses mouse models of chronic Lyme and a large clinical study to take a deeper look at Lyme disease. Why some patients make a protective immune response while others develop catastrophic responses like dysautonomia, MCAS, gynecological issues, or clotting disorders. How her team is moving beyond “yes/no” antibody tests to create new biomarker diagnostics that can guide treatments. Why sex differences matter in chronic illness and why women are more likely to experience long-term symptoms after infection. How her research could lead to more personalized treatment approaches for Lyme disease patients by grouping individuals based on immune response patterns. What samples (blood, saliva, sweat, tissue) her team is collecting at MIT to uncover new insights into chronic Lyme disease. Why this research brings hope to Lyme patients who feel unseen and unheard. About Dr. Michal Caspi Tal Principal Scientist, MIT Department of Biological Engineering Associate Scientific Director, MIT Center for Gynepathology Research Focus areas: Lyme disease, long COVID, chronic inflammatory diseases, sex differences in immune response, predictive diagnostics Background: PhD in Immunobiology from Yale (mentored by Dr. Akiko Iwasaki), postdoctoral training at Stanford (Irving Weissman lab), infectious disease research leader at Stanford’s Institute for Stem Cell Biology and Regenerative Medicine. Awards: NIH NIAID F31 and F32 Fellowships, Bay Area Lyme Foundation Emerging Leader Award About Project Lab Coat at New York Fashion Week Project Lab Coat was a groundbreaking event held on September 13, 2025, during New York Fashion Week (NYFW). The show brought together prominent celebrities, researchers, doctors, and advocates who were invited to walk the runway to spotlight Lyme disease and raise funds for Lyme disease research. For the first time, the global visibility of NYFW was used to highlight one of the fastest-growing infectious diseases in the world. Tick Boot Camp co-founders Matt Sabatello and Rich Johannesen, together with Dr. Tal, walked the runway at Project Lab Coat, joining leaders from medicine, science, entertainment, and advocacy. Project Lab Coat demonstrated the power of mainstream platforms to bring awareness, credibility, and resources to the fight against Lyme disease. Why This Episode Matters For too long, chronic Lyme patients have been told their symptoms are “all in their head.” Dr. Tal’s work at MIT proves otherwise by measuring the real biological differences in immune system responses. This research not only validates patients’ experiences but also charts a course toward better diagnostics, clinical trials, and personalized treatments.

In this episode of the Tick Boot Camp Podcast, we sit down with András Pal Bozsik, co-founder of Lyme Diagnostics Ltd and coordinator of the EU-funded DualDur® project, to discuss a disruptive new diagnostic technology that promises earlier, more accurate detection of Lyme disease. For decades, Lyme testing has relied on indirect serological methods that often miss early infection and fail chronic patients. András shares how his father’s pioneering work on Borrelia detection inspired the development of DualDur®, an AI-driven, direct detection system capable of finding Borrelia burgdorferi in blood samples at all stages of infection. We cover: Why current Lyme serology tests miss up to 60% of early infections How the DualDur® cell technology medium stabilizes and concentrates Borrelia for accurate identification The role of AI-powered automated microscopy in eliminating human error and improving sensitivity Scientific evidence of Borrelia’s genetic variation and shape-shifting every 2–3 weeks — explaining chronic infection and recurring IgM immune responses How DualDur testing can monitor treatment efficacy and guide Lyme-literate practitioners The debate over sexual transmission of Lyme and mother-to-child transmission risks Insights from clinical trials with 400 patients across Europe proving DualDur’s higher accuracy compared to standard methods The importance of combination antibiotic therapy, including overlooked options like ciprofloxacin, and why single antibiotics are rarely effective Plans to expand DualDur testing across Europe and eventually into the United States with FDA trials This groundbreaking conversation bridges science, technology, and patient care. It gives hope to millions of Lyme patients seeking a reliable test and effective treatment strategies. 🎧 Listen now to learn how DualDur could transform Lyme disease diagnostics and bring long-overdue answers to patients worldwide.

In this powerful episode of the Tick Boot Camp Podcast, we sit down with Ciara Gaglio, a 37-year-old from Woodside, Queens, New York, whose life was completely transformed by Lyme disease. Once a vibrant, social, and creative digital media professional, Ciara’s health began to unravel in her late 20s. What followed was nearly a decade of relentless symptoms, countless misdiagnoses, and visits to over 100 doctors before finally receiving a Lyme disease diagnosis at age 36. Ciara opens up about her devastating symptoms, including unrelenting fatigue, neurological issues, full-body pain, kidney distress, and the emotional toll of isolation. She shares her treatment journey—beginning with antibiotics like doxycycline and Rocephin through a PICC line, and later expanding to supportive therapies like herbs, probiotics, yoga, ozone therapy, and more. This candid conversation sheds light on the financial, emotional, and social impact of chronic Lyme disease, as well as the resilience required to keep advocating for yourself in a medical system that too often dismisses patients. Listen to Ciara’s journey of courage, humor, and persistence in the face of chronic Lyme disease. Her message is clear: be kind to yourself, advocate fiercely, and never give up.

In this episode of the Tick Boot Camp Podcast, we sit down with Janet Sperling, PhD, President of the Canadian Lyme Disease Foundation (CanLyme) and an accomplished entomologist whose research focuses on the bacterial microbiome of ticks across Canada. Janet’s journey with Lyme disease began when her teenage son was bitten by a tick during a family trip to California. His symptoms, starting with sinusitis and progressing to more severe illness, led to a long and frustrating medical journey involving multiple doctors, misdiagnoses, and eventually a clinical Lyme diagnosis supported by IGeneX testing. Janet shares her personal experience as a mother navigating the complexities of Lyme disease, as well as her professional expertise studying common tick species in Canada. Her research investigates the bacterial communities within these ticks, the role of bird migration in tick population spread, and the limitations of current microbiome analysis techniques. Key Discussion Points: Janet’s son’s Lyme disease story and the challenges of getting a diagnosis Differences in tick species and their bacterial microbiomes How environmental factors like bird migration contribute to the spread of tick-borne diseases The importance of prevention and early intervention in tick bite cases Why understanding tick biology is essential for public health policy in Canada How CanLyme is advancing Lyme disease research Lyme Disease Prevention Tips from Janet Sperling: Avoid tick bites by using protective clothing and repellents Perform thorough tick checks after outdoor activities Identify the tick species and feeding stage if bitten Consider tick testing when appropriate Whether you’re a Lyme patient, caregiver, or simply interested in the science behind ticks, this episode offers a unique blend of personal narrative and cutting-edge entomology research.

In this powerful episode of the Tick Boot Camp Podcast, dancer, actress, model, and Lyme warrior Renee LeeAnn Marsden shares her extraordinary journey of surviving late-stage Lyme disease, multiple co-infections, and autoimmune encephalitis. Once bedridden, disassociating, and in a wheelchair, Renee fought her way back through a combination of stem cells, peptides, neurofeedback, and faith — and now she’s thriving as a mother and advocate. From being misdiagnosed with MS and Parkinson’s to discovering mold illness, from devastating Herxheimer reactions to life-changing treatments at Amen Clinics, Renee’s story is a beacon of hope for anyone battling chronic Lyme or feeling hopeless in their healing journey. 🎧 In This Episode, You’ll Learn: Renee’s Lyme origin story – how years of tick bites, concussions, and a mission trip to South Africa triggered a health collapse. The neurological storm – how Lyme, autoimmune encephalitis, and brain inflammation caused terrifying disassociation, hallucinations, and hospitalizations. Treatment milestones – including IV therapies, ozone, stem cells (Infusio, umbilical cord stem cells), peptides, and PK Protocol. The Amen Clinics breakthrough – the brain scans, diagnoses, and therapies (SPM Active, neurofeedback, hyperbaric oxygen) that changed everything. The hidden enemy of mold – how mold exposure stalled Renee’s recovery until she identified and removed it. The power of mindset & faith – how saying “yes to life” even in crisis helped Renee keep pushing forward, from competing in Miss Tennessee in a wheelchair to inspiring others online. Motherhood after Lyme – how Renee navigated pregnancy and new motherhood after years of chronic illness. 📌 Why You Should Listen: Renee’s journey is a masterclass in resilience, faith, and integrative healing. Whether you’re battling Lyme disease, caring for someone who is, or looking for hope when treatments fail, this episode delivers insights on: Why prehab (building your body up) is critical before aggressive killing protocols. How trauma, concussions, and infections combine to impact the brain. Why you should never let Lyme become your identity. 🎙 About Renee: Renee LeeAnn Marsden – Actress, dancer, Lyme warrior, and founder of Bright Life Co., a faith-based wellness community for women. ✨ Key Quote from Renee: “You can’t wait until you feel better to live — you have to start saying yes to life where you are.”

Kaitlyn Oleinik is a chronic illness advocate and the author of Revival: My Journey with Neuropsychiatric Lyme Disease. She was bitten by a tick at age six and spent much of her life fighting an invisible illness while being dismissed by the medical system. Diagnosed with Lyme disease and co-infections in her teens, Kaitlyn has endured everything from hallucinations and involuntary psych holds to IVIG and stem cell treatments. Her book and voice give a name to the unspoken pain of countless others living with Lyme. 📘 About the Book Revival - My Journey with Neuropsychiatric Lyme Disease is Kaitlyn’s searing memoir that chronicles her descent into neuropsychiatric Lyme, including psychosis, hospitalizations, Morgellons disease, immune collapse, and ultimately, healing and redemption. It’s a must-read for patients, caregivers, and practitioners seeking to understand the lived experience of chronic Lyme. 🔑 Episode Highlights: Kaitlyn’s suspected tick bite at age 6 and onset of strange symptoms by age 10 Dismissed by dozens of doctors who claimed she was “too pretty to be sick” The psychological toll of not being believed—and being told it was all in her head Her first psychotic break, caused by inflammation and medication interactions Misdiagnoses including delusional parasitosis and bipolar disorder Treatments: IVIG, antibiotics, glutathione, intranasal stem cells, exosomes 5150 hold and the trauma of being institutionalized without understanding How residential treatment helped her begin to recover mentally and emotionally Rebuilding her identity after gaining 100+ lbs from steroids and losing her hair How she lost everything—then reclaimed her voice, purpose, and health Writing Revival - My Journey with Neuropsychiatric Lyme Disease as an act of truth-telling and healing 💬 Powerful Quotes: “The trauma wasn’t just from Lyme—it was from not being believed.” “They said it was all in my head. But it was in my blood, my brain, my cells.” “Revival means coming back from the dead. That’s what this journey felt like.” 🧪 Medical Takeaways: Lyme disease can manifest as psychiatric illness. “Delusional parasitosis” and “antibiomania” are misunderstood and under-researched. Proper treatment can be delayed for years by misdiagnosis and stigma. Complex chronic illness often requires multi-systemic treatment and trauma-informed care. 🙌 Why You Should Listen: Kaitlyn’s story is not just about Lyme - it’s about what happens when we stop believing women, ignore invisible illnesses, and turn away from complex suffering. Her story is a rallying cry for validation, medical reform, and hope.

In this powerful episode of the TIck Boot Camp Podcast, Dr. Jaquel Patterson, nationally recognized naturopathic physician and medical director of Fairfield Family Health, joins Matt Sabatello to explore the many layers of Lyme disease recovery – from hidden mold exposure to hormone balance and mental health support. Mold & Lyme Disease – Why mold toxicity can block Lyme recovery and how Dr. Patterson stages treatment so patients don’t get overwhelmed. Hormone Health – The vital role hormones play in energy, mood, joint health, and the ability to fight chronic infections. Mental Health & Lyme – How inflammation impacts the brain, leading to panic attacks, anxiety, depression, and brain fog — and how those symptoms can reverse with healing. Low Dose Immunotherapy (LDI) – What it is, how it retrains the immune system to stop overreacting, and why it’s helping Lyme patients stabilize. Inflammation & Flares – Practical tools like turmeric, hydration, and electrolytes to calm Herxheimer reactions and ease painful flare days. Environmental Toxins – How pesticides, polluted air, and contaminated water add to the burden — and realistic steps to reduce exposure. 💡 Episode Highlights: The patient case where mold, not Lyme, was the biggest roadblock to recovery. Why Dr. Patterson tests every patient’s hormones and what imbalances mean for recovery. How turmeric is one of her go-to remedies for both inflammation and mental clarity. Why hydration and detox aren’t “basic” — they can make or break a treatment plan. What makes LDI unique: a few drops every 6–8 weeks that can dramatically shift symptoms. 🎯 Who should listen? Anyone with Lyme disease who feels “stuck” or plateaued in their healing Parents of children with PANS/PANDAS or chronic infections Listeners curious about LDI, mold recovery, hormone balance, or functional medicine 📍 Resources & Links Mentioned in This Episode: Project Lab Coat – NYC Fashion Week Lyme Awareness Event Turmeric Forte by Mediherb CurcuPlex 95 by Xymogen Dr. Jaquel Pattesen, ND 🌟 About Dr. Jaquel Patterson: Dr. Patterson is a naturopathic physician and ILADS member known for her integrative work in Lyme disease, mold illness, mental health, hormone health, and immune system support.

In this powerful episode of the Tick Boot Camp Podcast, we are joined by Dr. Daniel Warren of Envita Medical Center, a leading voice in the field of regenerative and integrative medicine, to break down the multi-layered complexity of chronic Lyme disease and its treatment. Dr. Warren takes us deep into the root causes of persistent symptoms, highlighting how chronic Lyme often results in immune dysregulation, biofilm-protected pathogens, co-infections, and central nervous system inflammation that go untreated by conventional protocols. The conversation explores the use of VSELS (Very Small Embryonic Like Stem Cells) to regenerate damaged tissue and rebalance immune function, as well as IRAD (Insulin Receptor Antibiotic Delivery)—Envita’s proprietary method of delivering antibiotics past the blood-brain barrier to treat neurological Lyme disease. This episode is a must-listen for anyone seeking a deeper understanding of how precision diagnostics, immune modulation, and regenerative medicine can be integrated to support lasting recovery from chronic Lyme and tick-borne disease. 🧠 What You’ll Learn How Lyme disease disrupts immune signaling, leading to chronic symptoms Why traditional antibiotics often fail to reach the central nervous system How IRAD (Insulin Receptor Antibiotic Delivery) delivers antibiotics directly to the brain to treat neurological Lyme symptoms like brain fog, memory loss, and neuropathy How IRAD also helps rebalance neurotransmitters, reduce brain inflammation, and support better sleep The science and therapeutic promise of VSELS, stem cells that remain dormant and ageless until activated Why mitochondrial dysfunction, neurotoxins, and immune collapse are central to persistent Lyme cases How Envita’s diagnostic model uses advanced testing to personalize treatment protocols The role of co-infections, mold, and environmental toxins in complicating Lyme recovery How Dr. Warren and Envita are changing the landscape of chronic illness treatment with integrative, root-cause care 📍 Featured Guest Dr. Daniel Warren is a regenerative and integrative medicine specialist at Envita Medical Center in Scottsdale, Arizona. His clinical focus includes treating chronic, treatment-resistant conditions using a combination of targeted antimicrobial therapy, stem cell science, and immune reprogramming. Through protocols like VSELS and IRAD, Dr. Warren helps patients reclaim their lives from debilitating infections, neurological symptoms, and immune system failure. 📲 Resources & Links Learn more about Envita Medical Center Follow Tick Boot Camp on Instagram Subscribe to the Tick Boot Camp Podcast 📢 Share This Episode If you or a loved one is facing neurological Lyme symptoms, chronic fatigue, or treatment-resistant co-infections, this episode may hold the answers you’ve been searching for. Share it with your community and join us in raising awareness about the future of Lyme healing through regenerative medicine and targeted immune therapies.